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    NAA25 N-alpha-acetyltransferase 25, NatB auxiliary subunit [ Homo sapiens (human) ]

    Gene ID: 80018, updated on 3-Dec-2024

    Summary

    Official Symbol
    NAA25provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 25, NatB auxiliary subunitprovided by HGNC
    Primary source
    HGNC:HGNC:25783
    See related
    Ensembl:ENSG00000111300 MIM:612755; AllianceGenome:HGNC:25783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAP1; MDM20; C12orf30
    Summary
    This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.6), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NAA25 in Genome Data Viewer
    Location:
    12q24.13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112026689..112108783, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112003594..112085687, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112464493..112546587, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112448927-112449440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112449945-112450833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7043 Neighboring gene immediate early response 3 interacting protein 1 pseudogene Neighboring gene uncharacterized LOC124903021 Neighboring gene NANOG hESC enhancer GRCh37_chr12:112471007-112471508 Neighboring gene uncharacterized LOC124903022 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene microRNA 3657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112540436-112540936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112544255-112544756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4881 Neighboring gene Sharpr-MPRA regulatory region 5940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7046 Neighboring gene TRAF-type zinc finger domain containing 1 Neighboring gene microRNA 6861 Neighboring gene HECT domain E3 ubiquitin protein ligase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
    EBI GWAS Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
    EBI GWAS Catalog
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog
    Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
    EBI GWAS Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13089, DKFZp667K2112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NatB complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Names
    N-terminal acetyltransferase B complex subunit NAA25
    mitochondrial distribution and morphology 20
    natB complex subunit MDM20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017071.1 RefSeqGene

      Range
      5049..87143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024953.4NP_079229.2  N-alpha-acetyltransferase 25, NatB auxiliary subunit

      See identical proteins and their annotated locations for NP_079229.2

      Status: REVIEWED

      Source sequence(s)
      AA653507, BC047640, BC113587, BX647450
      Consensus CDS
      CCDS9159.1
      UniProtKB/Swiss-Prot
      A0JLU7, Q14CX7, Q6MZH1, Q7Z4N6, Q9H911
      UniProtKB/TrEMBL
      A8K8X0
      Related
      ENSP00000261745.4, ENST00000261745.9
      Conserved Domains (3) summary
      TIGR02917
      Location:22213
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:4773
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:264658
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      112026689..112108783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719606.3XP_006719669.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

      UniProtKB/TrEMBL
      A8K8X0
      Conserved Domains (3) summary
      sd00008
      Location:478505
      TPR_YbbN; TPR repeat [structural motif]
      sd00006
      Location:1945
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:235627
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
    2. XM_047429557.1XP_047285513.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

      UniProtKB/TrEMBL
      A8K8X0

    RNA

    1. XR_944730.4 RNA Sequence

    2. XR_243023.5 RNA Sequence

    3. XR_944731.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      112003594..112085687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373255.1XP_054229230.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

      UniProtKB/TrEMBL
      A8K8X0
    2. XM_054373254.1XP_054229229.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

      UniProtKB/TrEMBL
      A8K8X0

    RNA

    1. XR_008488680.1 RNA Sequence

    2. XR_008488678.1 RNA Sequence

    3. XR_008488679.1 RNA Sequence