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    IFNE interferon epsilon [ Homo sapiens (human) ]

    Gene ID: 338376, updated on 27-Nov-2024

    Summary

    Official Symbol
    IFNEprovided by HGNC
    Official Full Name
    interferon epsilonprovided by HGNC
    Primary source
    HGNC:HGNC:18163
    See related
    Ensembl:ENSG00000184995 MIM:615223; AllianceGenome:HGNC:18163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFN-E; IFNE1; IFNT1; INFE1; PRO655
    Summary
    Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; defense response to other organism; and lymphocyte activation involved in immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See IFNE in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (21480839..21482313, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (21495017..21496491, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21480838..21482312, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interferon alpha 1 Neighboring gene MIR31 host gene Neighboring gene interferon omega 1 pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19807 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:21487279-21487868 Neighboring gene NANOG hESC enhancer GRCh37_chr9:21504841-21505376 Neighboring gene microRNA 31 Neighboring gene small nucleolar RNA SNORD55/SNORD39

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119018, MGC119020

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type I interferon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interferon epsilon
    Names
    IFN-epsilon
    interferon epsilon 1
    interferon tau-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176891.5NP_795372.1  interferon epsilon precursor

      See identical proteins and their annotated locations for NP_795372.1

      Status: VALIDATED

      Source sequence(s)
      AL353732
      Consensus CDS
      CCDS34997.1
      UniProtKB/Swiss-Prot
      Q86WN2
      UniProtKB/TrEMBL
      A0A7R8GUQ9
      Related
      ENSP00000418018.2, ENST00000448696.4
      Conserved Domains (1) summary
      pfam00143
      Location:29186
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      21480839..21482313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      21495017..21496491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)