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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011858.3 RefSeqGene
- Range
-
5002..49814
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001083947.2 → NP_001077416.2 transmembrane protease serine 4 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 3). The splice acceptor site used for the first intron of this variant is polymorphic in the human population (rs2276122), and it is not known if this variant can be expressed from individuals with the 'A' allele.
- Source sequence(s)
-
AP000665, AP002800
- Consensus CDS
-
CCDS44743.1
- UniProtKB/TrEMBL
-
B7Z8X1
- Related
- ENSP00000430547.1, ENST00000522824.5
- Conserved Domains (3) summary
-
- smart00020
Location:199 → 424
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:108 → 192
- SRCR_2; Scavenger receptor cysteine-rich domain
-
NM_001173551.2 → NP_001167022.2 transmembrane protease serine 4 isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (4) lacks an internal 3-aa segment, compared to isoform 1.
- Source sequence(s)
-
AP000665, AP002800
- Consensus CDS
-
CCDS53716.1
- UniProtKB/TrEMBL
-
B7Z8X1
- Related
- ENSP00000435184.1, ENST00000534111.5
- Conserved Domains (3) summary
-
- smart00020
Location:202 → 427
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:56 → 90
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:106 → 195
- SRCR_2; Scavenger receptor cysteine-rich domain
-
NM_001173552.2 → NP_001167023.2 transmembrane protease serine 4 isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
- Source sequence(s)
-
AP000665, AP002800
- Consensus CDS
-
CCDS53717.1
- UniProtKB/TrEMBL
-
A0A087WTU6
- Related
- ENSP00000429209.1, ENST00000523251.5
- Conserved Domains (3) summary
-
- smart00020
Location:164 → 389
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:18 → 52
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:68 → 157
- SRCR_2; Scavenger receptor cysteine-rich domain
-
NM_001290094.2 → NP_001277023.2 transmembrane protease serine 4 isoform 6
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) uses an alternate splice junction at the end of a 5' exon compared to variant 1. The resulting isoform (6) is shorter at the N-terminus compared to isoform 1.
- Source sequence(s)
-
AP000665, AP002800
- UniProtKB/TrEMBL
-
B7Z900
- Conserved Domains (3) summary
-
- smart00020
Location:179 → 404
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:33 → 67
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:83 → 172
- SRCR_2; Scavenger receptor cysteine-rich domain
-
NM_001290096.2 → NP_001277025.2 transmembrane protease serine 4 isoform 7
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) uses alternate splice junctions at the ends of three different exons compared to variant 1. The resulting isoform (7) is shorter at the N-terminus and lacks a short internal segment compared to isoform 1.
- Source sequence(s)
-
AP000665, AP002800
- Consensus CDS
-
CCDS76482.1
- UniProtKB/TrEMBL
- B7Z458, E7ESG9
- Related
- ENSP00000428814.1, ENST00000522307.5
- Conserved Domains (1) summary
-
- smart00020
Location:57 → 282
- Tryp_SPc; Trypsin-like serine protease
-
NM_019894.4 → NP_063947.2 transmembrane protease serine 4 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The splice acceptor site used for the first intron of this variant is polymorphic in the human population (rs2276122), and it is not known if this variant can be expressed from individuals with the 'A' allele.
- Source sequence(s)
-
AP000665, AP002800
- Consensus CDS
-
CCDS31684.1
- UniProtKB/Swiss-Prot
- A8MU84, B0YJB0, B7Z8C5, E7ERX8, Q5XKQ6, Q6UX37, Q9NRS4, Q9NZA5
- UniProtKB/TrEMBL
-
B7Z8X1
- Related
- ENSP00000416037.3, ENST00000437212.8
- Conserved Domains (3) summary
-
- smart00020
Location:204 → 429
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- pfam15494
Location:108 → 197
- SRCR_2; Scavenger receptor cysteine-rich domain
RNA
-
NR_110734.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate splice junction at the end of a 5' exon and lacks an alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AP000665, AP002800
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000011.10 Reference GRCh38.p14 Primary Assembly
- Range
-
118077078..118125505
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005271613.5 → XP_005271670.1 transmembrane protease serine 4 isoform X1
- UniProtKB/TrEMBL
-
B7Z8X1
- Conserved Domains (4) summary
-
- smart00020
Location:204 → 429
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:205 → 432
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cl02509
Location:108 → 197
- SRCR_2; Scavenger receptor cysteine-rich domain
-
XM_011542901.3 → XP_011541203.1 transmembrane protease serine 4 isoform X3
- UniProtKB/TrEMBL
-
B7Z8X1
- Conserved Domains (4) summary
-
- smart00020
Location:199 → 424
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:200 → 427
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cl02509
Location:108 → 192
- SRCR_2; Scavenger receptor cysteine-rich domain
-
XM_011542902.3 → XP_011541204.1 transmembrane protease serine 4 isoform X5
- UniProtKB/TrEMBL
-
A0A087WTU6
- Conserved Domains (4) summary
-
- smart00020
Location:166 → 391
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:20 → 54
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:167 → 394
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cl02509
Location:70 → 159
- SRCR_2; Scavenger receptor cysteine-rich domain
-
XM_005271614.4 → XP_005271671.1 transmembrane protease serine 4 isoform X2
See identical proteins and their annotated locations for XP_005271671.1
- UniProtKB/TrEMBL
-
B7Z8X1
- Conserved Domains (4) summary
-
- smart00020
Location:202 → 427
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:56 → 90
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:203 → 430
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cl02509
Location:106 → 195
- SRCR_2; Scavenger receptor cysteine-rich domain
-
XM_047427259.1 → XP_047283215.1 transmembrane protease serine 4 isoform X4
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_005271615.4 → XP_005271672.1 transmembrane protease serine 4 isoform X6
- UniProtKB/TrEMBL
-
A0A087WTU6
- Conserved Domains (4) summary
-
- smart00020
Location:164 → 389
- Tryp_SPc; Trypsin-like serine protease
- cd00112
Location:18 → 52
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cd00190
Location:165 → 392
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
- cl02509
Location:68 → 157
- SRCR_2; Scavenger receptor cysteine-rich domain
-
XM_047427260.1 → XP_047283216.1 transmembrane protease serine 4 isoform X7
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_011542903.4 → XP_011541205.1 transmembrane protease serine 4 isoform X8
- UniProtKB/TrEMBL
- A0AAQ5BHV3, A0AAQ5BHV4
- Related
- ENSP00000519645.1, ENST00000714378.1
- Conserved Domains (3) summary
-
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:108 → 197
- SRCR_2; Scavenger receptor cysteine-rich domain
- cl21584
Location:205 → 304
- Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
-
XM_011542904.3 → XP_011541206.1 transmembrane protease serine 4 isoform X9
- Conserved Domains (2) summary
-
- cd00112
Location:58 → 92
- LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
- cl02509
Location:108 → 197
- SRCR_2; Scavenger receptor cysteine-rich domain
Alternate T2T-CHM13v2.0
Genomic
-
NC_060935.1 Alternate T2T-CHM13v2.0
- Range
-
118093464..118141906
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054369356.1 → XP_054225331.1 transmembrane protease serine 4 isoform X1
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_054369358.1 → XP_054225333.1 transmembrane protease serine 4 isoform X3
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_054369360.1 → XP_054225335.1 transmembrane protease serine 4 isoform X5
- UniProtKB/TrEMBL
-
A0A087WTU6
-
XM_054369357.1 → XP_054225332.1 transmembrane protease serine 4 isoform X2
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_054369359.1 → XP_054225334.1 transmembrane protease serine 4 isoform X4
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_054369361.1 → XP_054225336.1 transmembrane protease serine 4 isoform X6
- UniProtKB/TrEMBL
-
A0A087WTU6
-
XM_054369362.1 → XP_054225337.1 transmembrane protease serine 4 isoform X7
- UniProtKB/TrEMBL
-
B7Z8X1
-
XM_054369363.1 → XP_054225338.1 transmembrane protease serine 4 isoform X8
- UniProtKB/TrEMBL
-
A0AAQ5BHV3
-
XM_054369364.1 → XP_054225339.1 transmembrane protease serine 4 isoform X9
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_183247.1: Suppressed sequence
- Description
- NM_183247.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.