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    Usp16-45 Ubiquitin specific protease 16/45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31458, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp16-45provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 16/45provided by FlyBase
    Primary source
    FLYBASE:FBgn0029763
    Locus tag
    Dmel_CG4165
    See related
    AllianceGenome:FB:FBgn0029763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4165; Dmel\CG4165; Q9W4C3; usp16; Usp16; Usp45; USP45
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 19. Orthologous to several human genes including USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp16-45 in Genome Data Viewer
    Location:
    4F10-4F10; 1-11 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5421533..5427219)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5315566..5321252)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nutrient Amino Acid Transporter 1 Neighboring gene spoonbill Neighboring gene long non-coding RNA:CR45517 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
    2. Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. Hadad M, et al. Mech Dev, 2011 Sep-Dec. PMID 21983075
    3. RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in Drosophila. Du BB, et al. Yi Chuan, 2020 Dec 17. PMID 33509784
    4. fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Yagi Y, et al. Genes Cells, 2013 Nov. PMID 23919485
    5. The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Li L, et al. Development, 2013 Dec. PMID 24173801, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 16/45
    Names
    CG4165-PA
    CG4165-PB
    CG4165-PD
    CG4165-PE
    CG4165-PF
    Usp16-45-PA
    Usp16-45-PB
    Usp16-45-PD
    Usp16-45-PE
    Usp16-45-PF
    NP_001284890.1
    NP_572220.1
    NP_726993.1
    NP_726994.1
    NP_726995.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5421533..5427219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167037.2 → NP_726995.1  ubiquitin specific protease 16/45, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726995.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4C3
      Related
      FBpp0070738
      Conserved Domains (3) summary
      cd02667
      Location:849 → 1123
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:307 → 512
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:108 → 159
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. NM_001297961.1 → NP_001284890.1  ubiquitin specific protease 16/45, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4C3
      Conserved Domains (3) summary
      cd02667
      Location:849 → 1123
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:307 → 512
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:108 → 159
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. NM_131992.3 → NP_572220.1  ubiquitin specific protease 16/45, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4C3
      Related
      FBpp0070739
      Conserved Domains (3) summary
      cd02667
      Location:849 → 1123
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:307 → 512
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:108 → 159
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    4. NM_167035.2 → NP_726993.1  ubiquitin specific protease 16/45, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4C3
      Related
      FBpp0070741
      Conserved Domains (3) summary
      cd02667
      Location:849 → 1123
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:307 → 512
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:108 → 159
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    5. NM_167036.2 → NP_726994.1  ubiquitin specific protease 16/45, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4C3
      Related
      FBpp0309403
      Conserved Domains (3) summary
      cd02667
      Location:849 → 1123
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:307 → 512
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:108 → 159
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4C3 Q9W4C3
    Q9W4C3.1

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