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    osk oskar [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41066, updated on 17-Dec-2024

    Summary

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    Official Symbol
    oskprovided by FlyBase
    Official Full Name
    oskarprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003015
    Locus tag
    Dmel_CG10901
    See related
    AllianceGenome:FB:FBgn0003015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10901; Dm-osk; Dmel\CG10901; norka; Osk; OSK; Oskar
    Summary
    Enables mRNA binding activity. Involved in several processes, including axis specification; pole cell formation; and thermosensory behavior. Located in P granule; germ cell nucleus; and posterior cell cortex. Is expressed in several structures, including egg chamber; germarium region 2b; germline cell; ovary; and pole granule. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See osk in Genome Data Viewer
    Location:
    85B7-85B7; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8935126..8938395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4760848..4764117)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene polychaetoid Neighboring gene transfer RNA:Arginine-TCG 2-3 Neighboring gene transfer RNA:Arginine-TCG 2-4 Neighboring gene antisense RNA:CR44020 Neighboring gene long non-coding RNA:osk Neighboring gene Succinyl-coenzyme A synthetase beta subunit, ADP-forming Neighboring gene uncharacterized protein Neighboring gene ichor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Brightness through local constraint--LNA-enhanced FIT hybridization probes for in vivo ribonucleotide particle tracking. Hövelmann F, et al. Angew Chem Int Ed Engl, 2014 Oct 13. PMID 25167966
    2. Evolution of germ plasm assembly and function among the insects. Kemph A, et al. Curr Opin Insect Sci, 2022 Apr. PMID 35123121, Free PMC Article
    3. Evolution of a Cytoplasmic Determinant: Evidence for the Biochemical Basis of Functional Evolution of the Novel Germ Line Regulator Oskar. Blondel L, et al. Mol Biol Evol, 2021 Dec 9. PMID 34550378, Free PMC Article
    4. Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in Drosophila. Lehmann R, et al. Cell, 1986 Oct 10. PMID 3093084
    5. Tiny molecular beacons: LNA/2'-O-methyl RNA chimeric probes for imaging dynamic mRNA processes in living cells. Catrina IE, et al. ACS Chem Biol, 2012 Sep 21. PMID 22738327, Free PMC Article

    See all (798) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Localization of oskar mRNA by agglomeration in ribonucleoprotein granules.
      Title: Localization of oskar mRNA by agglomeration in ribonucleoprotein granules.
    2. Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
      Title: Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar.
    3. Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis.
      Title: Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis.
    4. Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila.
      Title: Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila.
    5. An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport.
      Title: An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport.
    6. Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development.
      Title: Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development.
    7. Different roles for the adjoining and structurally similar A-rich and poly(A) domains of oskar mRNA: Only the A-rich domain is required for oskar noncoding RNA function, which includes MTOC positioning.
      Title: Different roles for the adjoining and structurally similar A-rich and poly(A) domains of oskar mRNA: Only the A-rich domain is required for oskar noncoding RNA function, which includes MTOC positioning.
    8. Receptor-mediated yolk uptake is required for oskar mRNA localization and cortical anchorage of germ plasm components in the Drosophila oocyte.
      Title: Receptor-mediated yolk uptake is required for oskar mRNA localization and cortical anchorage of germ plasm components in the Drosophila oocyte.
    9. Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
      Title: Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyte.
    10. Bacterial contribution to genesis of the novel germ line determinant oskar.
      Title: Bacterial contribution to genesis of the novel germ line determinant oskar.
    Submit: New GeneRIF Correction See all GeneRIFs (64)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in P granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole cell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole cell formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pole plasm protein localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in posterior abdomen determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of oskar mRNA translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in posterior cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oskar
    Names
    CG10901-PA
    CG10901-PC
    dmoskar
    osk-PA
    osk-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8935126..8938395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206464.3 → NP_996186.1  oskar, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25158
      Conserved Domains (1) summary
      cd09972
      Location:16 → 98
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7

    2. NM_169248.4 → NP_731295.1  oskar, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731295.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25158, Q59DY0, Q95TT0, Q9V3P1
      UniProtKB/TrEMBL
      E8NH25
      Related
      FBpp0081435
      Conserved Domains (1) summary
      cd09972
      Location:154 → 236
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25158.1 P25158

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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