chn charlatan [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chnprovided by FlyBase
Official Full Name: charlatanprovided by FlyBase
Primary source: FLYBASE:FBgn0015371
Locus tag: Dmel_CG11798
See related: AllianceGenome:FB:FBgn0015371
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.13; CG11798; chl; Chn; clone 1.13; Dmel\CG11798; EPIL#6; EPIL6; l(2)02064; l(2)k04218; taco
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including larval somatic muscle development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; brain; head epidermis primordium; imaginal disc; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51E1-51E2; 2-74 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15115236..15144783)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11002741..11032288)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
Title: Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
Chn is a dual functional regulator of transcription.
Title: Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy.
Data show that isolated plasmatocytes can be triggered to differentiate into lamellocytes in vitro, either in response to Chn over-expression, or following activation of the JAK/STAT pathway.
Title: Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity.
under EGF signaling, double negative regulation mediated by the Ebi/SMRTER corepressor complex and an NRSF/REST-like factor, Chn, maintains inductive activity in developing photoreceptor cells by promoting Dl expression
Title: An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila.
mutation decreases the accumulation of Sc in proneural clusters, affecting notum macrochaetae, overexpression enhances ac/sc
Title: Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0298 (e-PCR)
- UniSTS:54418

Dm0788 (e-PCR)
- UniSTS:41165

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 15119372-15127796 mobile_element_type = transposon:Tirant{}833

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye cone cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: charlatan

Names: CG11798-PA; CG11798-PB; CG11798-PC; CG11798-PD; CG11798-PE; CG11798-PF; CG11798-PG; CG11798-PH; CG11798-PI; chn-PA; chn-PB; chn-PC; chn-PD; chn-PE; chn-PF; chn-PG; chn-PH; chn-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15115236..15144783

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001043082.2 → NP_001036547.1 charlatan, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036547.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZH6, Q0E968, Q5BHY4, Q7YU81, Q8T065, Q95RE7, Q9V788

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_206119.2 → NP_995841.1 charlatan, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995841.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YU81

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001259402.2 → NP_001246331.1 charlatan, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246331.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7A3

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001259405.2 → NP_001246334.1 charlatan, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246334.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7Q9

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001043081.2 → NP_001036546.1 charlatan, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036546.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YU81

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001259403.2 → NP_001246332.1 charlatan, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246332.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7A3

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001259401.2 → NP_001246330.1 charlatan, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246330.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7Z6

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001259404.2 → NP_001246333.1 charlatan, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246333.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K876

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_137169.4 → NP_611013.1 charlatan, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611013.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YU81

Related

FBpp0086546

Conserved Domains (1) summary

sd00017
Location:307 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]