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    knrl knirps-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    knrlprovided by FlyBase
    Official Full Name
    knirps-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001323
    Locus tag
    Dmel_CG4761
    See related
    AllianceGenome:FB:FBgn0001323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4761; Dmel\CG4761; knl; Knrl; NR0A2
    Summary
    Predicted to enable estrogen response element binding activity and nuclear receptor activity. Involved in negative regulation of DNA-templated transcription and regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; gut section; head epidermis primordium; and tracheal primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See knrl in Genome Data Viewer
    Location:
    77D4-77E1; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20597141..20620659, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20590241..20613759, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46326 Neighboring gene long noncoding RNA: testis-specific 3 Neighboring gene long non-coding RNA:CR44684 Neighboring gene long non-coding RNA:CR44683 Neighboring gene long non-coding RNA:CR44680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures. González-Gaitán M, et al. Proc Natl Acad Sci U S A, 1994 Aug 30. PMID 8078924, Free PMC Article
    2. The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Oro AE, et al. Nature, 1988 Dec 1. PMID 2848202
    3. The evolution of the knirps family of transcription factors in arthropods. Naggan Perl T, et al. Mol Biol Evol, 2013 Jun. PMID 23493255
    4. Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger. Rothe M, et al. EMBO J, 1989 Oct. PMID 2555153, Free PMC Article
    5. Steroid hormone receptor homologs in development. Oro AE, et al. Development, 1989. PMID 2699853

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell migration, open tracheal system TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    knirps-like
    Names
    CG4761-PA
    CG4761-PB
    Knirps-related
    knirps related
    knrl-PA
    knrl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20597141..20620659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176374.2 → NP_788552.1  knirps-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13054, Q9VPC8
      UniProtKB/TrEMBL
      A0A0S0WNG8
      Related
      FBpp0077870
      Conserved Domains (1) summary
      cl02596
      Location:12 → 96
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. NM_001316439.1 → NP_001303368.1  knirps-like, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13054, Q9VPC8
      UniProtKB/TrEMBL
      A0A0S0WNG8
      Conserved Domains (1) summary
      cl02596
      Location:12 → 96
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WNG8 A0A0S0WNG8
    P13054.1 P13054

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