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    Klp61F Kinesin-like protein at 61F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38135, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klp61Fprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 61Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004378
    Locus tag
    Dmel_CG9191
    See related
    AllianceGenome:FB:FBgn0004378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6345; CG9191; CG9191-PA; Dmel\CG9191; DmKlp61F; DmKLP61F; DmKRP130; KIF 8; KIF11; Kin-5; Kin5; Klp 61F; Klp2; KLP2; KLP61; klp61f; klp61F; Klp61f; KLP61f; KLP61F; Klp61F/KRP130; Krp130; KRP130; KRP[[(130)]]; KRP[[130]]; l(3)07012; l(3)6D283; l(3)Klp61F; urc; urcn
    Summary
    Enables microtubule binding activity and plus-end-directed microtubule motor activity. Involved in several processes, including microtubule cytoskeleton organization; plus-end directed microtubule sliding; and positive regulation of Golgi to plasma membrane protein transport. Located in several cellular components, including Golgi apparatus; fusome; and spindle. Part of kinesin complex. Colocalizes with centrosome. Is expressed in several structures, including CNS glial cell; gonad; head epidermis primordium; sensory nervous system primordium; and ventral nerve cord. Used to study microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Klp61F in Genome Data Viewer
    Location:
    61F4-61F4; 3-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1241568..1245910, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1241568..1245910, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45747 Neighboring gene galene Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables cytoskeletal motor activity PubMed 
    enables microtubule binding PubMed 
    enables microtubule binding  
    enables microtubule motor activity  
    enables plus-end-directed microtubule motor activity  
    enables plus-end-directed microtubule motor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in aster PubMed 
    colocalizes_with centrosome PubMed 
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in fusome PubMed 
    part_of kinesin complex PubMed 
    located_in microtubule PubMed 
    part_of microtubule associated complex PubMed 
    is_active_in mitotic spindle  
    located_in mitotic spindle PubMed 
    located_in mitotic spindle microtubule PubMed 
    located_in mitotic spindle pole PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in spindle PubMed 
    is_active_in spindle microtubule  

    General protein information

    Preferred Names
    Kinesin-like protein at 61F
    Names
    CG9191-PA
    Kinesin-related protein-130kD
    Kinesin8B
    Klp61F-PA
    kinesin-5
    kinesin-5 motor
    kinesin-5s
    kinesin-like protein
    urchin
    NP_476818.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1241568..1245910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057470.5 → NP_476818.1  Kinesin-like protein at 61F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46863, Q8T0A6, Q9W0I8
      UniProtKB/TrEMBL
      Q0PQ30, Q0PQ31
      Related
      FBpp0072616
      Conserved Domains (3) summary
      cd01364
      Location:17 → 365
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
      pfam00225
      Location:25 → 356
      Kinesin; Kinesin motor domain
      pfam13931
      Location:923 → 1009
      Microtub_bind; Kinesin-associated microtubule-binding
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