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    CG12935 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12935provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033547
    Locus tag
    Dmel_CG12935
    See related
    AllianceGenome:FB:FBgn0033547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12935
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and adult heart. Orthologous to human TMEM223 (transmembrane protein 223). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12935 in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10809397..10810655)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6696902..6698160)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene methuselah-like 13 Neighboring gene windei Neighboring gene uncharacterized protein Neighboring gene Nop10 ribonucleoprotein Neighboring gene Methyl methanesulfonate sensitivity 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Koizumi K, et al. Proc Natl Acad Sci U S A, 2007 Mar 27. PMID 17376868, Free PMC Article
    2. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article
    3. A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila. Feuillette S, et al. Front Neurosci, 2020. PMID 32116515, Free PMC Article
    4. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
    5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12935-PA
    CG12935-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10809397..10810655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136765.3 → NP_610609.1  uncharacterized protein Dmel_CG12935, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW07
      Related
      FBpp0087316
      Conserved Domains (1) summary
      pfam14640
      Location:59 → 229
      TMEM223; Transmembrane protein 223

    2. NM_001273943.1 → NP_001260872.1  uncharacterized protein Dmel_CG12935, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW07
      Conserved Domains (1) summary
      pfam14640
      Location:59 → 229
      TMEM223; Transmembrane protein 223
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JW07 Q7JW07

    Gene LinkOut

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