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    anchor anchor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    anchorprovided by FlyBase
    Official Full Name
    anchorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036741
    Locus tag
    Dmel_CG7510
    See related
    AllianceGenome:FB:FBgn0036741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-74EFa; CG7510; Dmel\CG7510
    Summary
    Involved in imaginal disc-derived wing vein morphogenesis and negative regulation of BMP signaling pathway. Predicted to be located in membrane. Is expressed in adult head; amnioserosa; embryonic/larval fat body; organism; and yolk nucleus. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See anchor in Genome Data Viewer
    Location:
    74E2-74E3; 3-45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17621824..17630971)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17614924..17624071)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 74EF Neighboring gene small Cajal body-specific RNA : MeU4-A65 Neighboring gene Vacuolar protein sorting 60 Neighboring gene long non-coding RNA:CR44566 Neighboring gene long non-coding RNA:CR44567

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anchor maintains gut homeostasis by restricting the JNK and Notch pathways in Drosophila. Wang J, et al. J Insect Physiol, 2021 Oct. PMID 34496279
    2. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
    3. Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster. Lyman RF, et al. Proc Biol Sci, 2023 Apr 12. PMID 37040806, Free PMC Article
    4. Anchor negatively regulates BMP signalling to control Drosophila wing development. Wang XC, et al. Eur J Cell Biol, 2018 May. PMID 29735293
    5. Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila. Adewoye AB, et al. J Biol Rhythms, 2017 Oct. PMID 28990443

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG7510 (Anchor) negatively regulates BMP signalling during wing development and vein formation.
      Title: Anchor negatively regulates BMP signalling to control Drosophila wing development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anchor
    Names
    CG7510-PA
    CG7510-PB
    anchor-PA
    anchor-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17621824..17630971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275066.1 → NP_001261995.1  anchor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFK5
      Conserved Domains (2) summary
      cd04443
      Location:871 → 953
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:53 → 387
      Mem_trans; Membrane transport protein

    2. NM_140741.3 → NP_648998.2  anchor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648998.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRD7, Q9VVJ0
      Related
      FBpp0074947
      Conserved Domains (2) summary
      cd04443
      Location:863 → 945
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl22894
      Location:53 → 387
      Mem_trans; Membrane transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFK5 M9PFK5
    Q95T60 Q95T60
    Q9VVJ0 Q9VVJ0

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