fs(1)M3 female sterile (1) M3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fs(1)M3provided by FlyBase
Official Full Name: female sterile (1) M3provided by FlyBase
Primary source: FLYBASE:FBgn0005390
Locus tag: Dmel_CG4790
See related: AllianceGenome:FB:FBgn0005390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4790; Dmel\CG4790; fs(1)K646; Fs(1)K646; fs(1)ph; fs(1)phl; fs(1)pole hole; fs(1)polehole
Summary: Predicted to enable heparin binding activity. Involved in terminal region determination; torso signaling pathway; and vitelline membrane formation involved in chorion-containing eggshell formation. Located in external side of plasma membrane and extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5958207..5964247, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5852240..5858280, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Required for cross-linkage of the vitelline membrane.
Title: Drosophila vitelline membrane cross-linking requires the fs(1)Nasrat, fs(1)polehole and chorion genes activities.
Nasrat and Polehole are essential for extracellular accumulation of Torso-like, a factor secreted during oogenesis that initiates Torso receptor activation (Polehole protein)
Title: Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitelline membrane formation involved in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed