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    Send1 Spermathecal endopeptidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33407, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Send1provided by FlyBase
    Official Full Name
    Spermathecal endopeptidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031406
    Locus tag
    Dmel_CG17012
    See related
    AllianceGenome:FB:FBgn0031406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17012; Dmel\CG17012; SP163
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in female accessory gland; seminal receptacle; and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Send1 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2254176..2255050, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2254176..2255050, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44787 Neighboring gene long non-coding RNA:CR44788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sperm-storage defects and live birth in Drosophila females lacking spermathecal secretory cells. Schnakenberg SL, et al. PLoS Biol, 2011 Nov. PMID 22087073, Free PMC Article
    2. Drosophila female reproductive glands contribute to mating plug composition and the timing of sperm ejection. McDonough-Goldstein CE, et al. Proc Biol Sci, 2022 Feb 9. PMID 35105240, Free PMC Article
    3. Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila. Panhuis TM, et al. Genetics, 2006 Aug. PMID 16783023, Free PMC Article
    4. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
    5. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A female reproductive tract expressed serine protease, GenBank Accession Number AM765858, that show increased transcription shortly after mating.
      Title: Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spermathecal endopeptidase 1
    Names
    CG17012-PA
    Send1-PA
    NP_608662.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2254176..2255050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134818.3 → NP_608662.1  spermathecal endopeptidase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0GST5, Q9VQA0
      Related
      FBpp0077481
      Conserved Domains (2) summary
      smart00020
      Location:29 → 239
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:30 → 239
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQA0 Q9VQA0

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