Pcyt2 Phosphocholine cytidylyltransferase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pcyt2provided by FlyBase
Official Full Name: Phosphocholine cytidylyltransferase 2provided by FlyBase
Primary source: FLYBASE:FBgn0035231
Locus tag: Dmel_CG18330
See related: AllianceGenome:FB:FBgn0035231
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cct2; Cct2; CCT2; CG18330; CT1187; Dmel\CG18330
Summary: Enables choline-phosphate cytidylyltransferase activity. Predicted to be involved in CDP-choline pathway. Located in cytoplasm. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to several human genes including PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1553493..1555315)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1553493..1555315)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CCT2 was identified as the cytoplasmic isoform.
Title: Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables choline-phosphate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables choline-phosphate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables choline-phosphate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

NP_647622.1

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The following sections contain reference sequences that belong to a specific genome build. Explain