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    CG6652 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6652provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036687
    Locus tag
    Dmel_CG6652
    See related
    AllianceGenome:FB:FBgn0036687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6652
    Summary
    Predicted to be involved in intraciliary transport. Located in axoneme. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 5. Orthologous to several human genes including LCA5L (lebercilin LCA5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6652 in Genome Data Viewer
    Location:
    73E4-73E4; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17020348..17022856, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17013448..17015956, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antennal protein 10 Neighboring gene Fermitin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila. Lapart JA, et al. Elife, 2019 Dec 10. PMID 31821146, Free PMC Article
    2. Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation. Wu Z, et al. PLoS Biol, 2024 Mar. PMID 38442096, Free PMC Article
    3. CEP290 is essential for the initiation of ciliary transition zone assembly. Wu Z, et al. PLoS Biol, 2020 Dec. PMID 33370260, Free PMC Article
    4. Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells. Vieillard J, et al. J Cell Biol, 2016 Sep 26. PMID 27646273, Free PMC Article
    5. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6652-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17020348..17022856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140689.4 → NP_648946.3  uncharacterized protein Dmel_CG6652 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648946.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TY6, Q9VVD0
      Related
      FBpp0075051
      Conserved Domains (3) summary
      pfam15619
      Location:82 → 257
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cd16269
      Location:239 → 250
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:151 → 252
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVD0 Q9VVD0

    Gene LinkOut

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