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    TTLL1A Tubulin tyrosine ligase-like 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TTLL1Aprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030823
    Locus tag
    Dmel_CG8918
    See related
    AllianceGenome:FB:FBgn0030823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8918; DmCG8918; Dmel\CG8918; TTLL1
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to be active in ciliary basal body. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL1A in Genome Data Viewer
    Location:
    15F2-15F2; 1-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17200726..17202598, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17094759..17096631, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene xmas Neighboring gene bazooka Neighboring gene long non-coding RNA:CR44026 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System. Devambez I, et al. Sci Rep, 2017 Nov 24. PMID 29176602, Free PMC Article
    2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    3. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Dai H, et al. Gene, 2006 Dec 30. PMID 17101240
    4. Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. Kim T, et al. Nat Immunol, 2005 Feb. PMID 15640802
    5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 1A
    Names
    CG8918-PA
    TTLL1A-PA
    NP_573197.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17200726..17202598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132969.3 → NP_573197.2  tubulin tyrosine ligase-like 1A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573197.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961I9, Q9VX74
      Related
      FBpp0074177
      Conserved Domains (1) summary
      pfam03133
      Location:107 → 419
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961I9 Q961I9
    Q9VX74 Q9VX74

    Gene LinkOut

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