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    Oga O-GlcNAcase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ogaprovided by FlyBase
    Official Full Name
    O-GlcNAcaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038870
    Locus tag
    Dmel_CG5871
    See related
    AllianceGenome:FB:FBgn0038870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5871; Dmel\CG5871; GlcNAcase; MGEA5; oga; OGA
    Summary
    Predicted to enable [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity and beta-N-acetylglucosaminidase activity. Involved in several processes, including N-glycan processing; locomotor rhythm; and protein O-linked glycosylation. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oga in Genome Data Viewer
    Location:
    93C6-93C7; 3-71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21219077..21222843)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17044799..17048565)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene SET and MYND domain containing, class 5 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44265 Neighboring gene Negative elongation factor A Neighboring gene ebony

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-GlcNAcase contributes to cognitive function in Drosophila. Muha V, et al. J Biol Chem, 2020 Jun 26. PMID 32094227, Free PMC Article
    2. Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila. Fenckova M, et al. PLoS Genet, 2022 May. PMID 35500025, Free PMC Article
    3. Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes. Akan I, et al. Cells, 2021 Apr 27. PMID 33925313, Free PMC Article
    4. Expression of β-1,4-galactosyltransferase and suppression of β-N-acetylglucosaminidase to aid synthesis of complex N-glycans in insect Drosophila S2 cells. Kim YK, et al. J Biotechnol, 2011 May 20. PMID 21501638
    5. Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway. Park S, et al. Cell Mol Life Sci, 2011 Oct. PMID 21365280, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. O-GlcNAcase contributes to cognitive function in Drosophila.
      Title: O-GlcNAcase contributes to cognitive function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    O-GlcNAcase
    Names
    CG5871-PA
    GlcNAcase
    Oga-PA
    NP_650956.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21219077..21222843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142699.3 → NP_650956.1  O-GlcNAcase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDC9
      Related
      FBpp0083452
      Conserved Domains (1) summary
      pfam07555
      Location:17 → 286
      NAGidase; beta-N-acetylglucosaminidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961J2 Q961J2
    Q9VDC9 Q9VDC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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