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    O-fut2 O-fucosyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    O-fut2provided by FlyBase
    Official Full Name
    O-fucosyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027791
    Locus tag
    Dmel_CG14789
    See related
    AllianceGenome:FB:FBgn0027791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14789; Dmel\CG14789; EG:BACN32G11.6; O-fut; O-FUT2; Ofut2; OFut2
    Summary
    Enables peptide-O-fucosyltransferase activity. Involved in O-glycan processing. Located in Golgi apparatus and endoplasmic reticulum. Orthologous to human POFUT2 (protein O-fucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See O-fut2 in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1464363..1465996, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1358396..1360029, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nucleostemin 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. Luo Y, et al. J Biol Chem, 2006 Apr 7. PMID 16464857
    2. Structures and functions of invertebrate glycosylation. Zhu F, et al. Open Biol, 2019 Jan 31. PMID 30958118, Free PMC Article
    3. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, et al. Genes Dev, 2008 Jul 15. PMID 18628395, Free PMC Article
    4. O-Linked glycosylation in Drosophila melanogaster. Zhang L, et al. Curr Opin Struct Biol, 2019 Jun. PMID 30852302, Free PMC Article
    5. Synthesis and biological roles of O-glycans in insects. Li W, et al. Glycoconj J, 2020 Feb. PMID 30937676

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results demonstrate that O-fucosyltransferase 2 is in fact a TSR-specific O-fucosyltransferase
      Title: Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptide-O-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-O-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-O-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-O-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in O-glycan processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein O-linked fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    O-fucosyltransferase 2
    Names
    CG14789-PA
    O-fut2-PA
    NP_569916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1464363..1465996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130560.4 → NP_569916.1  O-fucosyltransferase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K729, Q9U985, Q9W589
      Related
      FBpp0070283
      Conserved Domains (2) summary
      cd11298
      Location:73 → 460
      O-FucT-2; GDP-fucose protein O-fucosyltransferase 2
      pfam10250
      Location:78 → 454
      O-FucT; GDP-fucose protein O-fucosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W589.1 Q9W589

    Gene LinkOut

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