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    Reph Regulator of eph expression [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rephprovided by FlyBase
    Official Full Name
    Regulator of eph expressionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021800
    Locus tag
    Dmel_CG3920
    See related
    AllianceGenome:FB:FBgn0021800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3920; Dmel\CG3920; l(2)k16918; reph
    Summary
    Involved in ephrin receptor signaling pathway and peripheral nervous system development. Located in cytoplasm. Is expressed in several structures, including central brain primordium; eye disc morphogenetic furrow; ganglia; germline cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Reph in Genome Data Viewer
    Location:
    24C5-24C5; 2-11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3803545..3810671)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3803545..3810671)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene bark beetle Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44076

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe. Dearborn RE Jr, et al. PLoS One, 2012. PMID 22615969, Free PMC Article
    2. Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3. Bettencourt da Cruz A, et al. J Neurosci, 2008 Oct 22. PMID 18945896, Free PMC Article
    3. Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster. Galloni M, et al. Development, 1999 Jun. PMID 10225996
    4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
    5. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    regulator of eph expression
    Names
    CG3920-PA
    CG3920-PB
    Reph-PA
    Reph-PB
    lethal (2) k16918

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3803545..3810671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143795.4 → NP_652052.1  regulator of eph expression, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQV2
      Related
      FBpp0077186

    2. NM_164561.3 → NP_722945.2  regulator of eph expression, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722945.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRQ2
      Related
      FBpp0077187
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRQ2 Q8MRQ2
    Q9VQV2 Q9VQV2

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