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    Rab10 Rab10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33025, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rab10provided by FlyBase
    Official Full Name
    Rab10provided by FlyBase
    Primary source
    FLYBASE:FBgn0015789
    Locus tag
    Dmel_CG17060
    See related
    AllianceGenome:FB:FBgn0015789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF50924; CG17060; Dmel\CG17060; DmRab10; DRab10; DRAB10; O15971; Rab-r10; rab10
    Summary
    Predicted to enable GTPase activity and myosin V binding activity. Involved in several processes, including basal protein localization; growth of a germarium-derived egg chamber; and secretion by cell. Located in several cellular components, including basal part of cell; cell trailing edge; and lateral plasma membrane. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rab10 in Genome Data Viewer
    Location:
    19C1-19C1; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20251338..20254691)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20122412..20125717)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Peritrophin A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role for Rab10 in Methamphetamine-Induced Behavior. Vanderwerf SM, et al. PLoS One, 2015. PMID 26291453, Free PMC Article
    2. Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects. Ciampelli C, et al. Int J Mol Sci, 2023 Aug 10. PMID 37628835, Free PMC Article
    3. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Casler JC, et al. Mol Biol Cell, 2020 Dec 15. PMID 33112725, Free PMC Article
    4. Drosophila Embryonic Hemocytes Produce Laminins to Strengthen Migratory Response. Sánchez-Sánchez BJ, et al. Cell Rep, 2017 Nov 7. PMID 29117553, Free PMC Article
    5. Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons. Fellgett A, et al. J Parkinsons Dis, 2021. PMID 34250948, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
      Title: Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
    2. find that a Rab10-based secretion pathway promotes pericellular basement membranes protein accumulation and fibril formation
      Title: Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis.
    3. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag targets Rab10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
      Title: A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in basal protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basement membrane constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basolateral protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in growth of a germarium-derived egg chamber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell trailing edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body HDA PubMed 
    located_in recycling endosome HDA PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse HDA PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab10
    Names
    CG17060-PA
    Rab-protein 10
    Rab10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20251338..20254691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078695.4 → NP_523419.1  Rab10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O15971
      Related
      FBpp0077029
      Conserved Domains (1) summary
      cd01867
      Location:7 → 173
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15971 O15971

    Gene LinkOut

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