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    Ac78C Adenylyl cyclase 78C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40333, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ac78Cprovided by FlyBase
    Official Full Name
    Adenylyl cyclase 78Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024150
    Locus tag
    Dmel_CG10564
    See related
    AllianceGenome:FB:FBgn0024150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 78C; AC78C; CG10554; CG10564; DAC78C; DAC78C-s; dADCY8; Dmel\CG10564
    Summary
    Enables adenylate cyclase activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of sweet taste; response to caffeine; and response to disaccharide. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; antennal anlage; central brain anlage; dorsal ectoderm; and epithelial furrow. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ac78C in Genome Data Viewer
    Location:
    78B3-78C1; 3-47 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21136447..21171930, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21129547..21165030, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Asparagine synthetase Neighboring gene chromosome bows Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
    2. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
    3. Pigment-Dispersing Factor Signaling and Circadian Rhythms in Insect Locomotor Activity. Shafer OT, et al. Curr Opin Insect Sci, 2014 Jul 1. PMID 25386391, Free PMC Article
    4. Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration. Hertzler JI, et al. PLoS Genet, 2024 Aug. PMID 39186815, Free PMC Article
    5. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.
      Title: Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.
    2. We conclude that AC78C, via cAMP, participates in the sugar-taste signaling pathway at the low concentration range.
      Title: Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    mobile_element

    • Loc: c21143429-21143362 mobile_element_type = transposon:INE-1{}5891

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to caffeine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to sucrose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to trehalose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase 78C
    Names
    Ac78C-PB
    Ac78C-PC
    Ac78C-PD
    Ac78C-PE
    Ac78C-PF
    CG10564-PB
    CG10564-PC
    CG10564-PD
    CG10564-PE
    CG10564-PF
    adenylyl cyclase
    NP_001246857.1
    NP_001262137.1
    NP_001262138.1
    NP_001262139.1
    NP_524194.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21136447..21171930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275210.1 → NP_001262139.1  adenylyl cyclase 78C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD54, Q9U9I8, Q9Y1V0
      Conserved Domains (4) summary
      smart00044
      Location:525 → 728
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1380 → 1575
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:928 → 1019
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:287 → 550
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_001275209.1 → NP_001262138.1  adenylyl cyclase 78C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PID8, Q9U9I8, Q9Y1V0
      Conserved Domains (4) summary
      smart00044
      Location:526 → 729
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1381 → 1576
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:929 → 1020
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:288 → 551
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    3. NM_079470.5 → NP_524194.3  adenylyl cyclase 78C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524194.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NG95, Q9VP75, Q9VP76
      UniProtKB/TrEMBL
      Q9U9I8, Q9Y1V0
      Conserved Domains (4) summary
      smart00044
      Location:526 → 729
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1381 → 1576
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:929 → 1020
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:288 → 551
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    4. NM_001275208.1 → NP_001262137.1  adenylyl cyclase 78C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG27, Q9U9I8, Q9Y1V0
      Conserved Domains (4) summary
      smart00044
      Location:502 → 705
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1357 → 1552
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:905 → 996
      DUF1053; Domain of Unknown Function (DUF1053)
      pfam16214
      Location:264 → 527
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    5. NM_001259928.2 → NP_001246857.1  adenylyl cyclase 78C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KLG6
      Conserved Domains (3) summary
      smart00044
      Location:30 → 233
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:885 → 1080
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:433 → 524
      DUF1053; Domain of Unknown Function (DUF1053)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD54 M9PD54
    M9PG27 M9PG27
    M9PID8 M9PID8
    Q7KLG6 Q7KLG6
    Q9VP76.3 Q9VP76
    Q9Y1V0 Q9Y1V0

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