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    CG31064 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31064provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051064
    Locus tag
    Dmel_CG31064
    See related
    AllianceGenome:FB:FBgn0051064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14261; CG6001; Dmel\CG31064; RUFY1
    Summary
    Enables small GTPase binding activity. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31064 in Genome Data Viewer
    Location:
    97E10-97E10; 3-92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27229505..27239085, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23055227..23064807, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase alpha subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Callebaut I, et al. Trends Biochem Sci, 2001 Feb. PMID 11166556
    2. Endolysosomal trafficking controls yolk granule biogenesis in vitellogenic Drosophila oocytes. Yu Y, et al. PLoS Genet, 2024 Feb. PMID 38315726, Free PMC Article
    3. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Cheng LW, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157870, Free PMC Article
    4. Age-related ceRNA networks in adult Drosophila ageing. Yang D, et al. Front Genet, 2023. PMID 36926584, Free PMC Article
    5. Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep. Harbison ST, et al. PLoS Genet, 2017 Dec. PMID 29240764, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31064-PA
    CG31064-PB
    CG31064-PE
    CG31064-PF
    CG31064-PG
    CG31064-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27229505..27239085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170324.3 → NP_733203.1  uncharacterized protein Dmel_CG31064, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMP2
      Related
      FBpp0084495
      Conserved Domains (3) summary
      cd15721
      Location:665 → 726
      FYVE_RUFY1_like; FYVE domain found in RUN and FYVE domain-containing protein RUFY1, RUFY2 and similar proteins
      pfam02759
      Location:168 → 291
      RUN; RUN domain
      pfam08172
      Location:347 → 486
      CASP_C; CASP C terminal

    2. NM_001300631.1 → NP_001287560.1  uncharacterized protein Dmel_CG31064, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR8
      Conserved Domains (3) summary
      cd15721
      Location:813 → 874
      FYVE_RUFY1_like; FYVE domain found in RUN and FYVE domain-containing protein RUFY1, RUFY2 and similar proteins
      pfam02759
      Location:316 → 439
      RUN; RUN domain
      pfam08172
      Location:495 → 634
      CASP_C; CASP C terminal

    3. NM_001316619.1 → NP_001303548.1  uncharacterized protein Dmel_CG31064, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV26
      Conserved Domains (2) summary
      pfam02759
      Location:316 → 439
      RUN; RUN domain
      pfam08172
      Location:495 → 648
      CASP_C; CASP C terminal

    4. NM_001300630.1 → NP_001287559.1  uncharacterized protein Dmel_CG31064, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR2, C5WLQ7
      Conserved Domains (2) summary
      pfam02759
      Location:316 → 439
      RUN; RUN domain
      pfam08172
      Location:495 → 674
      CASP_C; CASP C terminal

    5. NM_143288.4 → NP_651545.2  uncharacterized protein Dmel_CG31064, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651545.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLQ7, Q8IMP0
      Related
      FBpp0084496
      Conserved Domains (2) summary
      pfam02759
      Location:363 → 486
      RUN; RUN domain
      pfam08172
      Location:542 → 721
      CASP_C; CASP C terminal

    6. NM_170325.3 → NP_733204.1  uncharacterized protein Dmel_CG31064, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMP1, Q961F7
      Related
      FBpp0084494
      Conserved Domains (2) summary
      pfam02759
      Location:168 → 291
      RUN; RUN domain
      pfam08172
      Location:347 → 526
      CASP_C; CASP C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHR2 A0A0B4LHR2
    A0A0B4LHR8 A0A0B4LHR8
    A0A126GV26 A0A126GV26
    Q86P45 Q86P45
    Q8IGZ4 Q8IGZ4
    Q8IMP0 Q8IMP0
    Q8IMP1 Q8IMP1
    Q8IMP2 Q8IMP2
    Q961F7 Q961F7

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