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    tHMG1 testis-enriched HMG-box-containing protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42650, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tHMG1provided by FlyBase
    Official Full Name
    testis-enriched HMG-box-containing protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038978
    Locus tag
    Dmel_CG7045
    See related
    AllianceGenome:FB:FBgn0038978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7045; Dmel\CG7045; thmg-1; tHMG-1
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Located in cytoplasm; nucleus; and polytene chromosome interband. Is expressed in male germline cell and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tHMG1 in Genome Data Viewer
    Location:
    94B1-94B1; 3-75 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22491829..22492381)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18317551..18318103)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 1 Neighboring gene testis-enriched HMG-box-containing protein 2 Neighboring gene Octopamine beta1 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. Xia S, et al. PLoS Genet, 2021 Jul. PMID 34242211, Free PMC Article
    2. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
    3. High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. Ragab A, et al. Genetics, 2006 Feb. PMID 16299391, Free PMC Article
    4. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447
    5. Copper homeostasis gene discovery in Drosophila melanogaster. Norgate M, et al. Biometals, 2007 Jun. PMID 17216353

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-enriched HMG-box-containing protein 1
    Names
    CG7045-PA
    tHMG1-PA
    testis-enriched HMG-box-containing protein-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22491829..22492381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142798.2 → NP_651055.1  testis-enriched HMG-box-containing protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV93, Q9VCZ5
      Related
      FBpp0083651
      Conserved Domains (2) summary
      cd01390
      Location:8 → 74
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam06501
      Location:55 → 116
      Herpes_U55; Human herpesvirus U55 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCZ5 Q9VCZ5

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