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    Ir93a Ionotropic receptor 93a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42471, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ir93aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 93aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259215
    Locus tag
    Dmel_CG42315
    See related
    AllianceGenome:FB:FBgn0259215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    93a; CG17274; CG17275; CG42315; CT35907; DmelIR93a; Dmel\CG42315; IR93; ir93a; IR93a
    Old locus tag
    Dmel_CG17274; Dmel_CG17275
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in several structures, including adult antennal lobe receptor neurons; antennal segment 3 sense organ; dorsal organ sensory neurons; synaptic neuropil domain; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ir93a in Genome Data Viewer
    Location:
    93A2-93A2; 3-69 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20851709..20859945, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16677431..16685667, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S30 Neighboring gene mir-1011 stem loop Neighboring gene Kainate-type ionotropic glutamate receptor subunit 1D Neighboring gene Turandot A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dynamic humidity arena to explore humidity-related behaviours in insects. Giri G, et al. J Exp Biol, 2024 Nov 1. PMID 39319429, Free PMC Article
    2. Honey Bee Parasitic Mite Contains the Sensilla-Rich Sensory Organ on the Foreleg Tarsus Expressing Ionotropic Receptors With Conserved Functions. Lei J, et al. Front Physiol, 2019. PMID 31143129, Free PMC Article
    3. Responses of different Drosophila species to temperature changes. Huda A, et al. J Exp Biol, 2022 Jun 1. PMID 35481475, Free PMC Article
    4. Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae. Tyrrell JJ, et al. PLoS Genet, 2021 Apr. PMID 33826603, Free PMC Article
    5. The impacts of hypertonic conditions on Drosophila larval cool cells. Bai H, et al. Front Cell Neurosci, 2024. PMID 39381503, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae.
      Title: Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae.
    2. Here, the authors discover Drosophila moist cells and show that they require IR25a and IR93a together with IR68a, a conserved, but orphan ionotropic receptor for hygrosensation.
      Title: Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila.
    3. The ionotropic receptors IR40a, IR93a, and IR25a are all required for humidity preference in D. melanogaster. Whereas IR40a is selectively required for hygrosensory responses, IR93a and IR25a mediate both humidity and temperature preference. Consistent with this, the expression of IR93a and IR25a includes thermosensory neurons of the arista.
      Title: Humidity Sensing in Drosophila.
    4. These results identify IR93a as a common component of molecularly and cellularly distinct ionotropic receptor pathways important for thermosensation and hygrosensation in insects.
      Title: Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ionotropic receptor 93a
    Names
    CG42315-PD
    Ir93a-PD
    NP_650924.3
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20851709..20859945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142667.3 → NP_650924.3  ionotropic receptor 93a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650924.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IH81, Q8T0V7, Q9VDH6, Q9VDH7
      Conserved Domains (2) summary
      pfam00060
      Location:576 → 836
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:429 → 697
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDH6.3 Q9VDH6

    Gene LinkOut

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