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    GC2 Glutamate Carrier 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GC2provided by FlyBase
    Official Full Name
    Glutamate Carrier 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037970
    Locus tag
    Dmel_CG12201
    See related
    AllianceGenome:FB:FBgn0037970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12201; Dmel\CG12201; DmGC2
    Summary
    Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head; organism; spermatozoon; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A18 (solute carrier family 25 member 18) and SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GC2 in Genome Data Viewer
    Location:
    87A4-87A4; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11971694..11972896)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7797416..7798618)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene aurora A Neighboring gene uncharacterized protein Neighboring gene Glutamate Carrier 1 Neighboring gene Transport and Golgi organization 9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative analysis of fruit fly and human glutamate dehydrogenases in Drosophila melanogaster sperm development. Vedelek V, et al. Front Cell Dev Biol, 2023. PMID 38020911, Free PMC Article
    2. Mitochondrial glutamate carriers from Drosophila melanogaster: biochemical, evolutionary and modeling studies. Lunetti P, et al. Biochim Biophys Acta, 2013 Oct. PMID 23850633
    3. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    4. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    5. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutamate carrier 2
    Names
    CG12201-PB
    CG12201-PD
    GC2-PB
    GC2-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11971694..11972896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141878.3 → NP_650135.2  glutamate carrier 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650135.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHE0
      Related
      FBpp0306271
      Conserved Domains (1) summary
      pfam00153
      Location:149 → 223
      Mito_carr; Mitochondrial carrier protein

    2. NM_169443.3 → NP_731657.2  glutamate carrier 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731657.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ3
      Related
      FBpp0081959
      Conserved Domains (2) summary
      PTZ00169
      Location:14 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:16 → 106
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8WHE0 A8WHE0
    Q8INJ3 Q8INJ3

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