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    TrpRS Tryptophanyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TrpRSprovided by FlyBase
    Official Full Name
    Tryptophanyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010803
    Locus tag
    Dmel_CG9735
    See related
    AllianceGenome:FB:FBgn0010803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    85D-WRS; Aats-trp; CG9735; Dmel\CG9735; dWARS; l(3)03559; l(3)03560; l(3)3559; wars; WRS; WRS-85D
    Summary
    Enables tryptophan-tRNA ligase activity. Involved in dendrite morphogenesis and tryptophanyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; and organism. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TrpRS in Genome Data Viewer
    Location:
    85D7-85D7; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9265027..9266904, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5090749..5092626, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting accessory protein 2 Neighboring gene salivary gland-expressed bHLH Neighboring gene Vacuolar protein sorting 16A Neighboring gene long non-coding RNA:CR46350

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Stitzinger SM, et al. Mol Gen Genet, 1999 Feb. PMID 10071220
    2. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Chihara T, et al. Nat Neurosci, 2007 Jul. PMID 17529987
    3. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
    4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    5. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tryptophanyl-tRNA synthetase
    Names
    CG9735-PB
    TrpRS-PB
    NP_524826.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9265027..9266904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080087.3 → NP_524826.1  Tryptophanyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI98, Q9U4Y1
      Related
      FBpp0081461
      Conserved Domains (2) summary
      PLN02486
      Location:45 → 426
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:115 → 422
      trpS; tryptophanyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KI98 Q0KI98
    Q9U4Y0 Q9U4Y0
    Q9U4Y1 Q9U4Y1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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