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    Sys1 Sys1 golgi trafficking protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sys1provided by FlyBase
    Official Full Name
    Sys1 golgi trafficking proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037603
    Locus tag
    Dmel_CG11753
    See related
    AllianceGenome:FB:FBgn0037603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11753; Dmel\CG11753; SYS1
    Summary
    Predicted to be involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human SYS1 (SYS1 golgi trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sys1 in Genome Data Viewer
    Location:
    85A5-85A5; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8652821..8653847)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4478543..4479569)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene MAP kinase kinase 4 Neighboring gene SRA stem-loop interacting RNA binding protein 2 Neighboring gene Dihydroorotate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene belle Neighboring gene pink Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity. Kanuka H, et al. Biochim Biophys Acta, 2005 Nov 30. PMID 16243437
    2. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article
    3. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sys1 golgi trafficking protein
    Names
    CG11753-PA
    CG11753-PB
    CG11753-PC
    Sys1-PA
    Sys1-PB
    Sys1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8652821..8653847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275448.1 → NP_001262377.1  Sys1 golgi trafficking protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFH6
      Conserved Domains (1) summary
      pfam09801
      Location:6 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    2. NM_141552.4 → NP_649809.1  Sys1 golgi trafficking protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHP1
      Related
      FBpp0081368
      Conserved Domains (1) summary
      pfam09801
      Location:6 → 149
      SYS1; Integral membrane protein S linking to the trans Golgi network

    3. NM_001275447.1 → NP_001262376.1  Sys1 golgi trafficking protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFH6
      Conserved Domains (1) summary
      pfam09801
      Location:6 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFH6 A0A0B4KFH6
    Q9VHP1 Q9VHP1

    Gene LinkOut

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