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    Nlg1 Neuroligin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nlg1provided by FlyBase
    Official Full Name
    Neuroligin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051146
    Locus tag
    Dmel_CG31146
    See related
    AllianceGenome:FB:FBgn0051146
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.256; CG12148; CG14596; CG31146; Dmel\CG31146; dnlg1; DNlg1; neuroligin; Nlg-1; nlg1
    Summary
    Enables neuroligin family protein binding activity. Involved in neurexin clustering involved in presynaptic membrane assembly and synaptic assembly at neuromuscular junction. Located in neuromuscular junction and postsynaptic membrane. Part of trans-synaptic protein complex. Is expressed in embryonic myoblast; embryonic/larval neuromuscular junction; larval somatic muscle cell; and ring gland. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN1 (neuroligin 1); NLGN2 (neuroligin 2); and NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nlg1 in Genome Data Viewer
    Location:
    84D11-84D12; 3-48 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7658247..7694874)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3483969..3520596)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neuroligin 3 Neighboring gene long non-coding RNA:CR44332 Neighboring gene long non-coding RNA:CR44260 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Remodeling of Active Zones Is Associated with Synaptic Homeostasis. Hong H, et al. J Neurosci, 2020 Apr 1. PMID 32122953, Free PMC Article
    2. Postsynaptic Syntaxin 4 negatively regulates the efficiency of neurotransmitter release. Harris KP, et al. J Neurogenet, 2018 Sep. PMID 30175640, Free PMC Article
    3. Neurexin and neuroligins jointly regulate synaptic degeneration at the Drosophila neuromuscular junction based on TEM studies. Guangming G, et al. Front Cell Neurosci, 2023. PMID 38026694, Free PMC Article
    4. Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila. Sun Y, et al. Commun Biol, 2023 Oct 18. PMID 37853189, Free PMC Article
    5. On the Teneurin track: a new synaptic organization molecule emerges. Mosca TJ. Front Cell Neurosci, 2015. PMID 26074772, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors find that axonal branch growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin. These adhesion complexes provide stability for filopodia by a 'stick-and-grow' based mechanism wholly independent of synaptic activity.
      Title: Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity.
    2. The disruption of DNlg1, DNlg2, or their presynaptic partner neurexin (DNrx) led to a dramatic decrease in the amount of F-actin. Further study showed that DNlg1, but not DNlg2 or DNlg3, directly interacts with the WRC via its C-terminal interacting receptor sequence.
      Title: Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction.
    3. dnlg1 mutants have reduced levels of Wit. Dnlg1 is required for proper localization and stability of Wit.
      Title: Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions.
    4. Genetic interaction experiments demonstrate Syx4, Syt4, and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
      Title: The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.
    5. presynaptic spinophilin fine-tunes neurexin/neuroligin signalling to control active zone number and functionality
      Title: Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
    6. Overexpression of dnlg1 in muscle resulted in synaptic overgrowth, but reduced the amplitudes of excitatory junctional currents.
      Title: Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuroligin family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurexin clustering involved in presynaptic membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of trans-synaptic protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroligin 1
    Names
    CG31146-PD
    CG31146-PE
    Neuroligin-1
    Nlg1-PD
    Nlg1-PE
    neuroligin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7658247..7694874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169191.4 → NP_731172.2  neuroligin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731172.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIC7
      Related
      FBpp0081065
      Conserved Domains (2) summary
      COG0657
      Location:263 → 408
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:153 → 710
      COesterase; Carboxylesterase family

    2. NM_001260037.2 → NP_001246966.1  neuroligin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIC7
      Conserved Domains (2) summary
      COG0657
      Location:263 → 408
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:153 → 710
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIC7 Q9VIC7

    Gene LinkOut

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