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    MAGE MAGE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAGEprovided by FlyBase
    Official Full Name
    MAGEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037481
    Locus tag
    Dmel_CG10059
    See related
    AllianceGenome:FB:FBgn0037481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10059; DMAGE; Dmel\CG10059; Mage; Nse3; sst
    Summary
    Involved in DNA damage response; negative regulation of neuroblast proliferation; and negative regulation of neuron apoptotic process. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in Bartter disease type 5; Prader-Willi syndrome; and Schaaf-Yang syndrome. Orthologous to several human genes including MAGEA8 (MAGE family member A8); MAGEB16 (MAGE family member B16); and MAGEB2 (MAGE family member B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MAGE in Genome Data Viewer
    Location:
    84C7-84C7; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7154238..7155180, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2979960..2980902, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GST-containing FLYWCH zinc-finger protein Neighboring gene Spindle assembly abnormal 4 Neighboring gene antisense RNA:CR45909 Neighboring gene stranded at second Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the first invertebrate MAGE paralogue: an epitope that activates T-cells in humans is highly conserved in evolution. Põld M, et al. Dev Comp Immunol, 2000 Dec. PMID 10906385
    2. Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis. Shimaji K, et al. Genes Cells, 2015 Nov. PMID 26334932
    3. Expression of Drosophila MAGE gene encoding a necdin homologous protein in postembryonic neurogenesis. Nishimura I, et al. Gene Expr Patterns, 2007 Jan. PMID 17084677
    4. Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis. Nishimura I, et al. Neuroscience, 2008 Jun 23. PMID 18479827
    5. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. Li X, et al. PLoS One, 2013. PMID 23555814, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAGE is involved in both neural stem cell proliferation and neuronal survival during nervous system development
      Title: Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis.
    2. These results indicate that MAGE expression lasts throughout the postembryonic neurogenesis in Drosophila.
      Title: Expression of Drosophila MAGE gene encoding a necdin homologous protein in postembryonic neurogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAGE
    Names
    CG10059-PA
    MAGE-PA
    necdin
    sleepless in seattle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7154238..7155180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141445.3 → NP_649702.2  MAGE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649702.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7L4, Q9ND98
      Related
      FBpp0081124
      Conserved Domains (1) summary
      pfam01454
      Location:36 → 201
      MAGE; MAGE family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7L4 Q9I7L4
    Q9ND98 Q9ND98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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