U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Achl Achilles [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36605, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Achlprovided by FlyBase
    Official Full Name
    Achillesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033936
    Locus tag
    Dmel_CG17386
    See related
    AllianceGenome:FB:FBgn0033936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Achn; CG17386; CT33484; Dmel\CG17386
    Summary
    Predicted to enable mRNA binding activity. Involved in negative regulation of gene expression. Predicted to be active in nucleus. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Achl in Genome Data Viewer
    Location:
    51A2-51A2; 2-71 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14420324..14424764)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10307829..10312269)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SAPK-interacting protein 1 Neighboring gene phyllopod Neighboring gene long non-coding RNA:CR45277

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development. Sheel A, et al. Front Cell Dev Biol, 2020. PMID 32850788, Free PMC Article
    2. Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila. Li J, et al. Brain Behav Immun, 2017 Mar. PMID 27856350, Free PMC Article
    3. The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor. Son W, et al. Genetics, 2020 Sep. PMID 32641295, Free PMC Article
    4. Achilles-Mediated and Sex-Specific Regulation of Circadian mRNA Rhythms in Drosophila. Li J, et al. J Biol Rhythms, 2019 Apr. PMID 30803307
    5. Aging and the clock: Perspective from flies to humans. De Nobrega AK, et al. Eur J Neurosci, 2020 Jan. PMID 30269400, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    achilles
    Names
    Achl-PA
    Achl-PB
    CG17386-PA
    CG17386-PB
    acheron

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14420324..14424764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299490.1 → NP_001286419.1  achilles, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9R1, Q5BI76
      Conserved Domains (2) summary
      cd08033
      Location:282 → 359
      LARP_6; La RNA-binding domain of La-related protein 6
      cd12289
      Location:373 → 472
      RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins

    2. NM_137120.3 → NP_610964.1  achilles, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9R1, Q5BI76
      Related
      FBpp0086617
      Conserved Domains (2) summary
      cd08033
      Location:282 → 359
      LARP_6; La RNA-binding domain of La-related protein 6
      cd12289
      Location:373 → 472
      RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9R1 A1Z9R1
    Q5BI76 Q5BI76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools