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    PIG-N Phosphatidylinositol glycan anchor biosynthesis class N [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Nprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Nprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033479
    Locus tag
    Dmel_CG2292
    See related
    AllianceGenome:FB:FBgn0033479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2292; Dmel\CG2292; DmPIG-N; PIGN
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-N in Genome Data Viewer
    Location:
    46E1-46E1; 2-62 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10063385..10066514, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5950890..5954019, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44298 Neighboring gene magu Neighboring gene Defensin Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene Cdc2-related kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila. Yamamoto-Hino M, et al. J Cell Sci, 2018 Oct 26. PMID 30266758, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class N
    Names
    CG2292-PA
    PIG-N-PA
    NP_610549.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10063385..10066514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136705.3 → NP_610549.1  phosphatidylinositol glycan anchor biosynthesis class N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z838, Q6NNX3
      Related
      FBpp0087517
      Conserved Domains (3) summary
      COG1524
      Location:10 → 265
      Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
      pfam04987
      Location:421 → 834
      PigN; Phosphatidylinositolglycan class N (PIG-N)
      cd16020
      Location:42 → 335
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z838 A1Z838

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