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    CG2065 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35707, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG2065provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033204
    Locus tag
    Dmel_CG2065
    See related
    AllianceGenome:FB:FBgn0033204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2065
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in adult fat body; adult head; gnathal primordium; larval foregut atrium; and yolk nucleus. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2065 in Genome Data Viewer
    Location:
    43E8-43E9; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7663786..7665269)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3551291..3552774)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor-like 43a Neighboring gene uncharacterized protein Neighboring gene Retinol dehydrogenase 1 Neighboring gene Dynactin 4, p62 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
    2. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. Moskalev A, et al. PLoS One, 2014. PMID 24475070, Free PMC Article
    3. Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Taliaferro JM, et al. Genes Dev, 2013 Feb 15. PMID 23392611, Free PMC Article
    4. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival T, et al. Eur J Neurosci, 2009 Apr. PMID 19519625, Free PMC Article
    5. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2065-PA
    CG2065-PB
    NP_001260787.1
    NP_610309.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7663786..7665269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273858.1 → NP_001260787.1  uncharacterized protein Dmel_CG2065, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYX2
      Conserved Domains (2) summary
      PRK06197
      Location:11 → 294
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:14 → 288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_136465.4 → NP_610309.1  uncharacterized protein Dmel_CG2065, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYX2
      Related
      FBpp0087996
      Conserved Domains (2) summary
      PRK06197
      Location:11 → 294
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:14 → 288
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYX2 Q7JYX2

    Gene LinkOut

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