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    Uevld UEV and lactate/malate dehyrogenase domains [ Mus musculus (house mouse) ]

    Gene ID: 54122, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uevldprovided by MGI
    Official Full Name
    UEV and lactate/malate dehyrogenase domainsprovided by MGI
    Primary source
    MGI:MGI:1860490
    See related
    Ensembl:ENSMUSG00000043262 AllianceGenome:MGI:1860490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Attp; 8430408E05Rik
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Predicted to be part of ESCRT I complex. Orthologous to human UEVLD (UEV and lactate/malate dehyrogenase domains). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.6), bladder adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uevld in Genome Data Viewer
    Location:
    7 B3; 7 30.63 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46572964..46608275, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46923216..46958532, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene mitochondrial sheath formation associated divergent transcript Neighboring gene elongin-B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 variant 3
    Names
    EV and lactate/malate dehydrogenase domain-containing protein
    UEV-3
    signaling molecule ATTP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040695.1 → NP_001035785.1  ubiquitin-conjugating enzyme E2 variant 3

      Status: VALIDATED

      Source sequence(s)
      AC090123, AK155685, CB524764
      Consensus CDS
      CCDS39965.1
      UniProtKB/Swiss-Prot
      O08761, Q3U1V6, Q7TQD3
      Related
      ENSMUSP00000091964.5, ENSMUST00000094398.13
      Conserved Domains (3) summary
      PLN02602
      Location:177 → 471
      PLN02602; lactate dehydrogenase
      pfam05743
      Location:21 → 138
      UEV; UEV domain
      cl21454
      Location:183 → 468
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46572964..46608275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540994.5 → XP_006541057.1  ubiquitin-conjugating enzyme E2 variant 3 isoform X1

      Conserved Domains (2) summary
      pfam05743
      Location:21 → 138
      UEV; UEV domain
      cl21454
      Location:183 → 359
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_006540993.5 → XP_006541056.1  ubiquitin-conjugating enzyme E2 variant 3 isoform X2

      Conserved Domains (2) summary
      pfam05743
      Location:21 → 138
      UEV; UEV domain
      cl21454
      Location:183 → 353
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_001785588.3 RNA Sequence

      Related
      ENSMUST00000207986.2

    2. XR_004934153.1 RNA Sequence

    3. XR_391352.5 RNA Sequence

    4. XR_391351.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016855.2: Suppressed sequence

      Description
      NM_016855.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1V6.1 GenPept UniProtKB/Swiss-Prot:Q3U1V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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