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    RFeSP Rieske iron-sulfur protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44390, updated on 17-Dec-2024

    Summary

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    Official Symbol
    RFeSPprovided by FlyBase
    Official Full Name
    Rieske iron-sulfur proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021906
    Locus tag
    Dmel_CG7361
    See related
    AllianceGenome:FB:FBgn0021906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey219; CG7361; Dmel\CG7361; dUQCRFS1; H; l(2)k11704; Noble; Q9VQ29; RfeSP; Rieske; RISP; UCRI; UQCR-RFeSP
    Summary
    Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RFeSP in Genome Data Viewer
    Location:
    22A3-22A3; 2-3 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1612429..1614160, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1612429..1614160, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hattifattener Neighboring gene no individualized sperm Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene long non-coding RNA:CR44603 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray. Garreau-Balandier I, et al. FEBS Lett, 2014 May 2. PMID 24642371
    2. Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster. Brischigliaro M, et al. J Mol Med (Berl), 2021 Oct. PMID 34274978, Free PMC Article
    3. Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Andreazza S, et al. Nat Commun, 2019 Jul 23. PMID 31337756, Free PMC Article
    4. Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein. Gontijo AM, et al. Nat Commun, 2011. PMID 21610726, Free PMC Article
    5. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Bosch JA, et al. Elife, 2022 Nov 8. PMID 36346220, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intron retention in the RFeSP gene generated a new protein.
      Title: Intron retention in the Drosophila melanogaster Rieske Iron Sulphur Protein gene generated a new protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    rieske iron-sulfur protein
    Names
    CG7361-PB
    CG7361-PD
    CG7361-PE
    Not out of the blue
    RFeSP-PB
    RFeSP-PD
    RFeSP-PE
    RIESKE IRON-SULFUR PROTEIN
    Ubiquinol-cytochrome C reductase iron-sulfur subunit
    Ubiquinol-cytochrome c oxidoreductase Iron-sulfur
    Ubiquinol-cytochrome c reductase rieske iron sulfur protein
    complex III
    rieske iron sulfur protein
    rieske iron sulphur protein
    rieske iron- sulfur protein of complex III
    NP_001259876.1
    NP_524748.2
    NP_722715.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1612429..1614160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272947.1 → NP_001259876.1  rieske iron-sulfur protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region

    2. NM_080009.4 → NP_524748.2  rieske iron-sulfur protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524748.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region

    3. NM_164426.3 → NP_722715.1  rieske iron-sulfur protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ28, Q9VQ29
      Related
      FBpp0077581
      Conserved Domains (3) summary
      cd03470
      Location:107 → 230
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:92 → 230
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:37 → 100
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ29 Q9VQ29

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