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    Cmtr1 Cap methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31355, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cmtr1provided by FlyBase
    Official Full Name
    Cap methyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029693
    Locus tag
    Dmel_CG6379
    See related
    AllianceGenome:FB:FBgn0029693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6379; CMTr1; dCMTR1; Dmel\CG6379
    Summary
    Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and RISC complex assembly. Located in cytoplasm and nucleus. Is expressed in adult head. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cmtr1 in Genome Data Viewer
    Location:
    4A5-4A5; 1-6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4097592..4101031, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3991625..3995064, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46349 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum group A-like Neighboring gene brainiac

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CMTr mediated 2'-O-ribose methylation status of cap-adjacent nucleotides across animals. Dix TC, et al. RNA, 2022 Oct. PMID 35970556, Free PMC Article
    2. Roles for Drosophila cap1 2'-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2. Lee S, et al. Insect Biochem Mol Biol, 2020 Aug. PMID 32504809
    3. CMTr cap-adjacent 2'-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses. Haussmann IU, et al. Nat Commun, 2022 Mar 8. PMID 35260552, Free PMC Article
    4. A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites. Mishra S, et al. Life Sci Alliance, 2024 Jun. PMID 38499328, Free PMC Article
    5. Biochemical identification of new proteins involved in splicing repression at the Drosophila P-element exonic splicing silencer. Horan L, et al. Genes Dev, 2015 Nov 1. PMID 26545814, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RISC complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of intracellular mRNA localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Cap methyltransferase 1
    Names
    CG6379-PA
    CG6379-PB
    Cmtr1-PA
    Cmtr1-PB
    cap1 2'-O-MTase
    cap1 2'-O-ribose methyltransferase
    NP_001284851.1
    NP_572148.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4097592..4101031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297922.1 → NP_001284851.1  Cap methyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9YI61, Q8SYG1, Q9W4N2
      UniProtKB/TrEMBL
      T2GGJ9
      Conserved Domains (2) summary
      pfam01585
      Location:25 → 69
      G-patch; G-patch domain
      pfam01728
      Location:172 → 383
      FtsJ; FtsJ-like methyltransferase

    2. NM_131920.4 → NP_572148.2  Cap methyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572148.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9YI61, Q8SYG1, Q9W4N2
      UniProtKB/TrEMBL
      T2GGJ9
      Related
      FBpp0070639
      Conserved Domains (2) summary
      pfam01585
      Location:25 → 69
      G-patch; G-patch domain
      pfam01728
      Location:172 → 383
      FtsJ; FtsJ-like methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4N2.1 Q9W4N2
    T2GGJ9 T2GGJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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