SPARC Secreted protein, acidic, cysteine-rich [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SPARCprovided by FlyBase
Official Full Name: Secreted protein, acidic, cysteine-richprovided by FlyBase
Primary source: FLYBASE:FBgn0026562
Locus tag: Dmel_CG6378
See related: AllianceGenome:FB:FBgn0026562
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey291; BM-40 Sparc; BM-40-SPARC; BM-40/SPARC; BM40; CG6378; CT19876; Dmel\CG6378; dsparc; dSparc; dSPARC; sparc; Sparc
Summary: Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including Malpighian tubule development; extracellular matrix organization; and larval fat body development. Located in extracellular space. Is expressed in several structures, including CNS glial cell; embryonic/larval hemocyte; embryonic/larval midgut primordium; ganglia; and germ layer. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to several human genes including SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97D3-97D3; 3-92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26869238..26871995, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22694960..22697717, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The predicted collagen-binding domains of Drosophila SPARC are essential for survival and for collagen IV distribution and assembly into basement membranes.
Title: The predicted collagen-binding domains of Drosophila SPARC are essential for survival and for collagen IV distribution and assembly into basement membranes.
The data implicate SPARC in the noncell autonomous control of cardiac function in Drosophila and suggest that modulation of SPARC gene expression may ameliorate cardiac dysfunction in humans.
Title: SPARC-Dependent Cardiomyopathy in Drosophila.
Egg chamber elongation requires temporal down-regulation of SPARC.
Title: Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila.
SPARC has a critical role in the proper basal lamina assembly in Drosophila fat body
Title: Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster.
Drosophila Sparc is identified as an early marker transcriptionally upregulated in loser cells that provides a transient protection by inhibiting Caspase activation in outcompeted cells.
Title: Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition.
SPARC is required for basal lamina maturation and condensation of the ventral nerve cord during Drosophila embryogenesis.
Title: Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryos.
data suggest that the production and assembly of dSPARC in the basal lamina is dependent on type IV collagen, and raise the possibility that dSPARC and type IV collagen interactions are prerequisite to assembly and structural integrity of basal laminae
Title: Evolutionary conservation and association of SPARC with the basal lamina in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in extracellular matrix constituent secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval fat body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in trachea development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secreted protein, acidic, cysteine-rich

Names: BM-40-SPARC; BM-40-secreted protein acidic and rich in cysteine; CG6378-PA; CG6378-PB; SPARC-PA; SPARC-PB; osteonectin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26869238..26871995 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143252.4 → NP_651509.2 secreted protein, acidic, cysteine-rich, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651509.2

Status: REVIEWED

UniProtKB/TrEMBL

O97365, Q8SY75, Q9VBB0

Related

FBpp0084464

Conserved Domains (3) summary

cd00252
Location:170 → 292

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

cd01328
Location:85 → 168

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

pfam10591
Location:169 → 278

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
NM_001276069.1 → NP_001262998.1 secreted protein, acidic, cysteine-rich, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262998.1

Status: REVIEWED

UniProtKB/TrEMBL

O97365, Q8SY75, Q9VBB0

Conserved Domains (3) summary

cd00252
Location:170 → 292

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

cd01328
Location:85 → 168

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

pfam10591
Location:169 → 278

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region