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    Ccdc6 coiled-coil domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 76551, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc6provided by MGI
    Official Full Name
    coiled-coil domain containing 6provided by MGI
    Primary source
    MGI:MGI:1923801
    See related
    Ensembl:ENSMUSG00000048701 AllianceGenome:MGI:1923801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810012H18Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytosol. Orthologous to human CCDC6 (coiled-coil domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 13.7), bladder adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc6 in Genome Data Viewer
    Location:
    10 B5.3; 10 36.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (69932709..70029030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (70096878..70193200)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin 3, epithelial Neighboring gene STARR-seq mESC enhancer starr_27063 Neighboring gene predicted gene, 33416 Neighboring gene predicted gene, 33361 Neighboring gene STARR-seq mESC enhancer starr_27068 Neighboring gene STARR-seq mESC enhancer starr_27069 Neighboring gene STARR-positive B cell enhancer ABC_E5146 Neighboring gene STARR-seq mESC enhancer starr_27073 Neighboring gene predicted gene, 51771 Neighboring gene uncharacterized LOC118567787 Neighboring gene myoregulin Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity. Leone V, et al. Oncotarget, 2015 Jun 20. PMID 25970781, Free PMC Article
    2. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    3. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111121.2 → NP_001104591.1  coiled-coil domain-containing protein 6

      See identical proteins and their annotated locations for NP_001104591.1

      Status: VALIDATED

      Source sequence(s)
      AC132435
      Consensus CDS
      CCDS48591.1
      UniProtKB/Swiss-Prot
      D3YZP9
      Related
      ENSMUSP00000123374.2, ENSMUST00000147545.8
      Conserved Domains (1) summary
      pfam09755
      Location:45 → 330
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      69932709..70029030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514276.4 → XP_006514339.1  coiled-coil domain-containing protein 6 isoform X1

      Conserved Domains (1) summary
      pfam09755
      Location:45 → 330
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)

    2. XM_006514277.4 → XP_006514340.1  coiled-coil domain-containing protein 6 isoform X2

      Conserved Domains (1) summary
      pfam09755
      Location:13 → 248
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YZP9.1 GenPept UniProtKB/Swiss-Prot:D3YZP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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