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    Samd14 sterile alpha motif domain containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 217125, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Samd14provided by MGI
    Official Full Name
    sterile alpha motif domain containing 14provided by MGI
    Primary source
    MGI:MGI:2384945
    See related
    Ensembl:ENSMUSG00000047181 AllianceGenome:MGI:2384945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; calcium-mediated signaling; and neuron projection development. Predicted to be active in several cellular components, including actin cytoskeleton; dendrite; and postsynaptic density. Is expressed in liver lobe; nervous system; neural retina; and olfactory epithelium. Orthologous to human SAMD14 (sterile alpha motif domain containing 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 45.4), CNS E14 (RPKM 40.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Samd14 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94900213..94916913)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95009395..95026087)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sarcoglycan, alpha (dystrophin-associated glycoprotein) Neighboring gene H1.9 linker histone Neighboring gene STARR-positive B cell enhancer ABC_E7047 Neighboring gene STARR-seq mESC enhancer starr_30478 Neighboring gene STARR-seq mESC enhancer starr_30479 Neighboring gene STARR-positive B cell enhancer ABC_E3995 Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94859496-94859731 Neighboring gene predicted gene, 51875 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 2 Neighboring gene predicted gene, 53200 Neighboring gene predicted gene 11513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. Ray S, et al. Elife, 2022 Jun 17. PMID 35713400, Free PMC Article
    2. Sterile α-motif domain requirement for cellular signaling and survival. Ray S, et al. J Biol Chem, 2020 May 15. PMID 32241909, Free PMC Article
    3. Physiological and regenerative functions of sterile-α motif protein-14 in hematopoiesis. Schaefer MA, et al. Exp Hematol, 2023 Dec. PMID 37722652, Free PMC Article
    4. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Hewitt KJ, et al. Dev Cell, 2017 Aug 7. PMID 28787589, Free PMC Article
    5. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Physiological and regenerative functions of sterile-alpha motif protein-14 in hematopoiesis.
      Title: Physiological and regenerative functions of sterile-α motif protein-14 in hematopoiesis.
    2. Functional requirements for a Samd14-capping protein complex in stress erythropoiesis.
      Title: Functional requirements for a Samd14-capping protein complex in stress erythropoiesis.
    3. The Samd14 enhancer is essential for erythrocyte regeneration in severe anemia.
      Title: GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31049

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sterile alpha motif domain-containing protein 14
    Names
    SAM domain-containing protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364135.1 → NP_001351064.1  sterile alpha motif domain-containing protein 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606480
      Conserved Domains (2) summary
      cd09512
      Location:323 → 388
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      cl28033
      Location:45 → 236
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. NM_001364136.1 → NP_001351065.1  sterile alpha motif domain-containing protein 14 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606480
      Conserved Domains (1) summary
      cd09512
      Location:255 → 320
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

    3. NM_146025.2 → NP_666137.1  sterile alpha motif domain-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_666137.1

      Status: VALIDATED

      Source sequence(s)
      AI854782, AK049753, BC034054
      Consensus CDS
      CCDS25269.1
      UniProtKB/Swiss-Prot
      Q5SWB7, Q8BHE2, Q8C8N5, Q8K070
      Related
      ENSMUSP00000062231.4, ENSMUST00000055947.10
      Conserved Domains (2) summary
      cd09512
      Location:321 → 386
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00454
      Location:323 → 386
      SAM; Sterile alpha motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94900213..94916913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248936.4 → XP_011247238.1  sterile alpha motif domain-containing protein 14 isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:45 → 236
      PHA03307; transcriptional regulator ICP4; Provisional
      cl15755
      Location:317 → 336
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_030245857.2 → XP_030101717.1  sterile alpha motif domain-containing protein 14 isoform X3

      Conserved Domains (2) summary
      PHA03307
      Location:39 → 234
      PHA03307; transcriptional regulator ICP4; Provisional
      cl15755
      Location:315 → 334
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_006533011.4 → XP_006533074.1  sterile alpha motif domain-containing protein 14 isoform X1

      Conserved Domains (1) summary
      cd09512
      Location:309 → 374
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K070.1 GenPept UniProtKB/Swiss-Prot:Q8K070

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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