RhoL Rho-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RhoLprovided by FlyBase
Official Full Name: Rho-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0014380
Locus tag: Dmel_CG9366
See related: AllianceGenome:FB:FBgn0014380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 9366; anon-EST:CL1c2; CG9366; D-RhoL; Dmel\CG9366; DmRHO-L; Drac3; DRhoL; G; Mes1; Rac3; RhoG; rhol; rhoL; Rhol; RhoL/Rac3; rol
Summary: Predicted to enable GTPase activity. Involved in several processes, including border follicle cell migration; hemopoiesis; and melanotic encapsulation of foreign target. Is expressed in several structures, including adult head; embryonic ventral epidermis; epithelium; hemocyte; and mesoderm. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3) and RHOH (ras homolog family member H). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85D18-85D18; 3-48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9497101..9502581, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5322823..5328303, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0560 (e-PCR)
- UniSTS:68146

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rho-like

Names: CG9366-PA; CG9366-PB; Rho-Like; RhoL-PA; RhoL-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9497101..9502581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260074.1 → NP_001247003.1 Rho-like, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247003.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMW7

Conserved Domains (2) summary

smart00174
Location:38 → 202

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd00157
Location:36 → 198

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
NM_079568.3 → NP_524292.1 Rho-like, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524292.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24192, Q541G3, Q9U5D4, Q9VHC9

Related

FBpp0081602

Conserved Domains (2) summary

smart00174
Location:14 → 178

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd00157
Location:12 → 174

Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)