park parkin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: parkprovided by FlyBase
Official Full Name: parkinprovided by FlyBase
Primary source: FLYBASE:FBgn0041100
Locus tag: Dmel_CG10523
See related: AllianceGenome:FB:FBgn0041100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAN12155.1; CG10523; Dmel\CG10523; dpark; Dpark; dparkin; dParkin; dPARKIN; dpk; Park; PARK; park1; PARK2; Parkin; PARKIN; pk; PK; prkn; SD01679
Summary: Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitochondrion organization; protein ubiquitination; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in germarium region 2b; head; oocyte; and organism. Used to study Parkinson's disease; Parkinson's disease 2; Parkinson's disease 6; cardiomyopathy; and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 78C2-78C2; 3-47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21194754..21196853, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21187854..21189953, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of Ca[2+] phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
Title: Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models.
Title: PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models.
Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.
Title: Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.
Differential mitochondrial roles for alpha-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Title: Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.
Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
Title: Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Title: The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Atg1-mediated autophagy suppresses tissue degeneration in Pink1/Parkin mutants by promoting mitochondrial fission in Drosophila.
Title: Atg1-mediated autophagy suppresses tissue degeneration in pink1/parkin mutants by promoting mitochondrial fission in Drosophila.
These studies showed that the mt-Keima Drosophila system is a useful tool for understanding the role and molecular mechanism of mitophagy in vivo and the essential role of the PINK1-Parkin pathway in mitophagy induction in response to mitochondrial dysfunction.
Title: Assessment of mitophagy in mt-Keima Drosophila revealed an essential role of the PINK1-Parkin pathway in mitophagy induction in vivo.
changes observed in the brains of these Drosophila models of Parkinson's Disease, in which mitochondrial ligases MUL1 and PARKIN do not function, may explain the mechanisms of some neurological and behavioural symptoms of PD.
Title: Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models.
Parkin directly binds to TAF15 and that parkin overexpression can suppress the defective phenotypes of neurodegenerative diseases.
Title: Genetic activation of parkin rescues TAF15-induced neurotoxicity in a Drosophila model of amyotrophic lateral sclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitochondrial fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy of mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type 2 mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: parkin

Names: CG10523-PB; CG10523-PC; D-parkin; dparkin; ortholog of PRKN; park-PB; park-PC; parkin F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21194754..21196853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168884.2 → NP_730600.1 parkin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730600.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KTX7, Q86CZ3, Q86LE7, Q95TI4

Related

FBpp0077974

Conserved Domains (5) summary

smart00647
Location:334 → 390

IBR; In Between Ring fingers

cd01798
Location:32 → 105

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:435 → 471

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:249 → 339

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:159 → 250

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
NM_168885.3 → NP_730601.1 parkin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730601.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KTX7, Q86CZ3, Q86LE7, Q95TI4

Related

FBpp0077975

Conserved Domains (5) summary

smart00647
Location:334 → 390

IBR; In Between Ring fingers

cd01798
Location:32 → 105

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam01485
Location:435 → 471

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:249 → 339

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:159 → 250

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin