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    Zfp536 zinc finger protein 536 [ Mus musculus (house mouse) ]

    Gene ID: 243937, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp536provided by MGI
    Official Full Name
    zinc finger protein 536provided by MGI
    Primary source
    MGI:MGI:1926102
    See related
    Ensembl:ENSMUSG00000043456 AllianceGenome:MGI:1926102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf536; mKIAA0390; 9630010P11Rik
    Summary
    Enables retinoic acid-responsive element binding activity. Acts upstream of or within negative regulation of neuron differentiation and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; future brain; genitourinary system; nervous system; and sensory organ. Orthologous to human ZNF536 (zinc finger protein 536). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.6), CNS E14 (RPKM 1.5) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp536 in Genome Data Viewer
    Location:
    7 B2- B3; 7 24.57 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (37017448..37473733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (37318023..37774039, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38439 Neighboring gene predicted gene 28077 Neighboring gene predicted gene, 30544 Neighboring gene predicted gene, 30483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:38218361-38218562 Neighboring gene STARR-seq mESC enhancer starr_18668 Neighboring gene predicted gene, 51477 Neighboring gene STARR-seq mESC enhancer starr_18670 Neighboring gene RIKEN cDNA 4930505M18 gene Neighboring gene STARR-seq mESC enhancer starr_18671 Neighboring gene predicted gene, 22302 Neighboring gene STARR-positive B cell enhancer ABC_E8166 Neighboring gene STARR-positive B cell enhancer ABC_E6537 Neighboring gene URI1, prefoldin-like chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Qin Z, et al. Mol Cell Biol, 2009 Jul. PMID 19398580, Free PMC Article
    2. Functional genomic analysis of oligodendrocyte differentiation. Dugas JC, et al. J Neurosci, 2006 Oct 25. PMID 17065439, Free PMC Article
    3. Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene. Mattiske T, et al. Hum Mol Genet, 2016 Dec 15. PMID 27798109
    4. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Sandberg M, et al. Neuron, 2016 Sep 21. PMID 27657450, Free PMC Article
    5. Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Zhou J, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Dec. PMID 29055695

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify a novel zinc finger protein, ZNF536, that negatively regulates neuron differentiation
      Title: ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription.
    2. ZFP536 promotes the late phase of oligodendrocyte differentiation.
      Title: Functional genomic analysis of oligodendrocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid-responsive element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 536

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404091.1 → NP_001391020.1  zinc finger protein 536 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC133950, AC140213
      UniProtKB/Swiss-Prot
      Q80U15, Q8K083
      Related
      ENSMUSP00000135068.2, ENSMUST00000176205.8

    2. NM_001404093.1 → NP_001391022.1  zinc finger protein 536 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    3. NM_001404094.1 → NP_001391023.1  zinc finger protein 536 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    4. NM_001404095.1 → NP_001391024.1  zinc finger protein 536 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    5. NM_001404096.1 → NP_001391025.1  zinc finger protein 536 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    6. NM_001404097.1 → NP_001391026.1  zinc finger protein 536 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    7. NM_001404099.1 → NP_001391028.1  zinc finger protein 536 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    8. NM_001404100.1 → NP_001391029.1  zinc finger protein 536 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133648, AC133950, AC140213

    9. NM_172385.3 → NP_759017.1  zinc finger protein 536 isoform a

      See identical proteins and their annotated locations for NP_759017.1

      Status: VALIDATED

      Source sequence(s)
      AC133950, AC140213
      Consensus CDS
      CCDS21156.1
      UniProtKB/Swiss-Prot
      Q80U15, Q8K083
      Related
      ENSMUSP00000058468.7, ENSMUST00000056338.13
      Conserved Domains (5) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam16606
      Location:657 → 737
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    RNA

    1. NR_175807.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133950
      Related
      ENSMUST00000176137.2

    2. NR_175808.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133950

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      37017448..37473733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153106.1 → XP_036008999.1  zinc finger protein 536 isoform X3

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:345 → 367
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:730 → 753
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 718
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    2. XM_017322250.3 → XP_017177739.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    3. XM_017322245.3 → XP_017177734.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    4. XM_036153102.1 → XP_036008995.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    5. XM_036153099.1 → XP_036008992.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    6. XM_017322247.2 → XP_017177736.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    7. XM_036153100.1 → XP_036008993.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    8. XM_036153107.1 → XP_036009000.1  zinc finger protein 536 isoform X3

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:345 → 367
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:730 → 753
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 718
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    9. XM_036153105.1 → XP_036008998.1  zinc finger protein 536 isoform X3

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:345 → 367
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:145 → 169
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:730 → 753
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 718
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    10. XM_017322246.2 → XP_017177735.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    11. XM_011250580.4 → XP_011248882.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    12. XM_030242573.2 → XP_030098433.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    13. XM_036153101.1 → XP_036008994.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    14. XM_017322249.3 → XP_017177738.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    15. XM_036153098.1 → XP_036008991.1  zinc finger protein 536 isoform X1

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    16. XM_036153104.1 → XP_036008997.1  zinc finger protein 536 isoform X2

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

    17. XM_036153103.1 → XP_036008996.1  zinc finger protein 536 isoform X2

      Conserved Domains (6) summary
      COG5048
      Location:103 → 180
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:755 → 775
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:767 → 789
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:781 → 804
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam16606
      Location:657 → 739
      zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K083.1 GenPept UniProtKB/Swiss-Prot:Q8K083

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