Zg16 zymogen granule protein 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zg16provided by MGI
Official Full Name: zymogen granule protein 16provided by MGI
Primary source: MGI:MGI:1916286
See related: Ensembl:ENSMUSG00000049350 AllianceGenome:MGI:1916286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZG16p; 1810010M01Rik
Summary: Enables peptidoglycan binding activity. Acts upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in mucus layer. Orthologous to human ZG16 (zymogen granule protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 2660.4), small intestine adult (RPKM 1563.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.3 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126649328..126651847, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127050156..127052675, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZG16 impacts gut microbiota-associated intestinal inflammation and pulmonary mucosal function through bacterial metabolites.
Title: ZG16 impacts gut microbiota-associated intestinal inflammation and pulmonary mucosal function through bacterial metabolites.
The more penetrable Zg16(-/-) mucus allowed Gram-positive bacteria to translocate to systemic tissues. Viable bacteria were found in spleen and were associated with increased abdominal fat pad mass in Zg16(-/-) animals. The function of ZG16 reveals a mechanism for keeping bacteria further away from the host colon epithelium.
Title: Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.
ZG16p mRNA is downregulated in chronic pancreatitis.
Title: Differential expression of the trypsin inhibitor SPINK3 mRNA and the mouse ortholog of secretory granule protein ZG-16p mRNA in the mouse pancreas after repetitive injury.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within suppression of symbiont entry into host	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in mucus layer	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zymogen granule membrane protein 16

Names: secretory lectin ZG16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026918.3 → NP_081194.1 zymogen granule membrane protein 16 precursor

See identical proteins and their annotated locations for NP_081194.1

Status: VALIDATED

Source sequence(s)

AC122863

Consensus CDS

CCDS21856.1

UniProtKB/Swiss-Prot

Q8K0C5

Related

ENSMUSP00000145876.2, ENSMUST00000205424.2

Conserved Domains (1) summary

cd09611
Location:31 → 158

Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins