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    Hspa12b heat shock protein 12B [ Mus musculus (house mouse) ]

    Gene ID: 72630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hspa12bprovided by MGI
    Official Full Name
    heat shock protein 12Bprovided by MGI
    Primary source
    MGI:MGI:1919880
    See related
    Ensembl:ENSMUSG00000074793 AllianceGenome:MGI:1919880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700081N06Rik
    Summary
    Predicted to enable ATP binding activity. Is expressed in nervous system; retina; smooth muscle tissue; and stomach. Orthologous to human HSPA12B (heat shock protein family A (Hsp70) member 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 21.1), subcutaneous fat pad adult (RPKM 16.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hspa12b in Genome Data Viewer
    Location:
    2 F1; 2 63.27 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130969332..130987905)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131127412..131145985)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig-like lectin 1, sialoadhesin Neighboring gene STARR-seq mESC enhancer starr_05699 Neighboring gene predicted gene, 30378 Neighboring gene STARR-seq mESC enhancer starr_05701 Neighboring gene adipose secreted signaling protein Neighboring gene predicted gene 14232 Neighboring gene sperm flagellar 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS. Fan M, et al. Shock, 2022 Oct 1. PMID 36256626, Free PMC Article
    2. HSPA12B attenuates acute lung injury during endotoxemia in mice. Zhang X, et al. Int Immunopharmacol, 2015 Dec. PMID 26428851
    3. Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction. Fan M, et al. JCI Insight, 2020 Sep 17. PMID 32790647, Free PMC Article
    4. HSPA12B is predominantly expressed in endothelial cells and required for angiogenesis. Steagall RJ, et al. Arterioscler Thromb Vasc Biol, 2006 Sep. PMID 16825593
    5. Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis. Zhang R, et al. PLoS One, 2014. PMID 24977412, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS.
      Title: LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS.
    2. Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction.
      Title: Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction.
    3. Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.
      Title: Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.
    4. Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
      Title: Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
    5. HSPA12B promoted functional recovery and survival after stroke in an eNOS-dependent mechanism.
      Title: HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.
    6. These results demonstrate a pulmonary protective effect of HSPA12B against endotoxin challenge, which indicates management of HSPA12B expression could serve as a potential therapeutic target for ALI during sepsis/septic shock.
      Title: HSPA12B attenuates acute lung injury during endotoxemia in mice.
    7. HSPA12B plays a protective role in vascular endothelial barrier dysfunction by preserving the endothelial permeability during sepsis.
      Title: Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.
    8. Results suggest that miR-134 might influence neuronal cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by negatively modulating HSPA12B protein expression in a posttranscriptional manner
      Title: Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B.
    9. Results show that downregulation of miR-134 could induce neuroprotection against ischemic injury by upregulation of HSPA12B protein expression in vivo and in vitro models
      Title: Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B.
    10. Plasma extracellular HSPA12B is elevated in both septic mice and patients.
      Title: Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 12B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028306.3 → NP_082582.1  heat shock 70 kDa protein 12B

      See identical proteins and their annotated locations for NP_082582.1

      Status: PROVISIONAL

      Source sequence(s)
      AL831736
      Consensus CDS
      CCDS16755.1
      UniProtKB/Swiss-Prot
      Q9CZJ2
      Related
      ENSMUSP00000096950.4, ENSMUST00000099349.10
      Conserved Domains (1) summary
      cl17037
      Location:61 → 529
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130969332..130987905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239793.3 → XP_011238095.1  heat shock 70 kDa protein 12B isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:1 → 335
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_006500245.5 → XP_006500308.1  heat shock 70 kDa protein 12B isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1 → 271
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZJ2.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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