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    Cep89 centrosomal protein 89 [ Mus musculus (house mouse) ]

    Gene ID: 72140, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cep89provided by MGI
    Official Full Name
    centrosomal protein 89provided by MGI
    Primary source
    MGI:MGI:1919390
    See related
    Ensembl:ENSMUSG00000023072 AllianceGenome:MGI:1919390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc123; 2610507L03Rik
    Summary
    Predicted to be involved in cilium assembly and mitochondrion organization. Located in centriole and motile cilium. Part of ciliary transition fiber. Is expressed in cerebral cortex. Orthologous to human CEP89 (centrosomal protein 89). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.4), CNS E11.5 (RPKM 8.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Cep89 in Genome Data Viewer
    Location:
    7 B2; 7 21.37 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35096425..35139255)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35396999..35439830)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene predicted gene, 51476 Neighboring gene STARR-positive B cell enhancer ABC_E699 Neighboring gene Fanconi anemia core complex associated protein 24 Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chemical synaptic transmission  
    involved_in cilium assembly  
    acts_upstream_of_or_within cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in non-motile cilium assembly  
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole PubMed 
    located_in centriole  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    part_of ciliary transition fiber  
    part_of ciliary transition fiber PubMed 
    part_of ciliary transition fiber  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrial intermembrane space  
    located_in motile cilium PubMed 
    located_in non-motile cilium  
    located_in spindle pole  
    located_in spindle pole  
    located_in synapse  

    General protein information

    Preferred Names
    centrosomal protein of 89 kDa
    Names
    coiled-coil domain containing 123
    coiled-coil domain-containing protein 123, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028120.3NP_082396.1  centrosomal protein of 89 kDa

      See identical proteins and their annotated locations for NP_082396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding variant.
      Source sequence(s)
      AC151535, AK012067, AK029107
      Consensus CDS
      CCDS39911.1
      UniProtKB/Swiss-Prot
      Q8C127, Q9CZX2
      Related
      ENSMUSP00000078383.6, ENSMUST00000079414.12
      Conserved Domains (1) summary
      cl15415
      Location:458540
      Sec1; Sec1 family

    RNA

    1. NR_153799.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC151535, AC154126

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      35096425..35139255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153454.1XP_036009347.1  centrosomal protein of 89 kDa isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:7243
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004934188.1 RNA Sequence

    2. XR_004934187.1 RNA Sequence

    3. XR_004934189.1 RNA Sequence

      Related
      ENSMUST00000141704.8
    4. XR_391104.4 RNA Sequence

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