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    Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 110834, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrna3provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 3provided by MGI
    Primary source
    MGI:MGI:87887
    See related
    Ensembl:ENSMUSG00000032303 AllianceGenome:MGI:87887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    (a)3; Acra3; Acra-3; A730007P14Rik
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; chronic obstructive pulmonary disease; cocaine dependence; lung cancer (multiple); and nicotine dependence. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 6.2), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Chrna3 in Genome Data Viewer
    Location:
    9 B; 9 29.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54917401..54933846, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55010117..55026562, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene hydroxylysine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6734 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome subunit alpha 4 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway  
    involved_in acetylcholine receptor signaling pathway  
    acts_upstream_of_or_within activation of transmembrane receptor protein tyrosine kinase activity PubMed 
    acts_upstream_of_or_within behavioral response to nicotine PubMed 
    involved_in behavioral response to nicotine  
    acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in membrane depolarization  
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transmembrane transport  
    involved_in nervous system development  
    involved_in neuromuscular synaptic transmission  
    involved_in presynaptic modulation of chemical synaptic transmission  
    acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission PubMed 
    acts_upstream_of_or_within regulation of dendrite morphogenesis PubMed 
    acts_upstream_of_or_within regulation of membrane potential PubMed 
    acts_upstream_of_or_within regulation of muscle contraction PubMed 
    acts_upstream_of_or_within regulation of smooth muscle contraction PubMed 
    involved_in response to acetylcholine  
    involved_in response to nicotine  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction  
    acts_upstream_of_or_within synaptic transmission involved in micturition PubMed 
    involved_in synaptic transmission involved in micturition  
    involved_in synaptic transmission, cholinergic  
    acts_upstream_of_or_within synaptic transmission, cholinergic PubMed 
    Items 1 - 25 of 26
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    part_of acetylcholine-gated channel complex  
    part_of acetylcholine-gated channel complex PubMed 
    part_of acetylcholine-gated channel complex  
    is_active_in cholinergic synapse PubMed 
    is_active_in cholinergic synapse PubMed 
    is_active_in cholinergic synapse  
    located_in dendrite  
    is_active_in dopaminergic synapse  
    located_in endoplasmic reticulum  
    is_active_in neuron projection  
    located_in neuronal cell body  
    located_in nuclear speck  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft  
    located_in postsynaptic membrane PubMed 
    is_active_in postsynaptic specialization membrane PubMed 
    is_active_in postsynaptic specialization membrane  
    part_of protein-containing complex  
    is_active_in synapse  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-3
    Names
    alpha 3
    neuronal nicotinic acetylcholine receptor, alpha 3 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145129.3NP_660111.3  neuronal acetylcholine receptor subunit alpha-3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC156832, AC161264
      Consensus CDS
      CCDS23199.2
      UniProtKB/Swiss-Prot
      Q8BV44, Q8R4G9
      UniProtKB/TrEMBL
      Q8VHH6
      Related
      ENSMUSP00000034851.6, ENSMUST00000034851.7
      Conserved Domains (2) summary
      TIGR00860
      Location:24490
      LIC; Cation transporter family protein
      cd19016
      Location:29235
      LGIC_ECD_nAChR_A3; extracellular domain of nicotinic acetylcholine receptor subunit alpha 3 (CHRNA3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54917401..54933846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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