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    Cx3cr1 C-X3-C motif chemokine receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 13051, updated on 17-Dec-2024

    Summary

    Official Symbol
    Cx3cr1provided by MGI
    Official Full Name
    C-X3-C motif chemokine receptor 1provided by MGI
    Primary source
    MGI:MGI:1333815
    See related
    Ensembl:ENSMUSG00000052336 AllianceGenome:MGI:1333815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCX3CR1
    Summary
    Enables C-X3-C chemokine binding activity and C-X3-C chemokine receptor activity. Involved in several processes, including antifungal innate immune response; central nervous system development; and synapse organization. Located in cell surface. Is expressed in several structures, including brain; colon; genitourinary system; head mesenchyme; and meninges. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 7.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cx3cr1 in Genome Data Viewer
    Location:
    9 F4; 9 71.37 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119877749..119897362, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120048683..120068296, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3866 Neighboring gene predicted gene, 33800 Neighboring gene STARR-seq mESC enhancer starr_25485 Neighboring gene STARR-seq mESC enhancer starr_25486 Neighboring gene STARR-positive B cell enhancer ABC_E9780 Neighboring gene xin actin-binding repeat containing 1 Neighboring gene predicted gene, 33858 Neighboring gene STARR-seq mESC enhancer starr_25492 Neighboring gene C-C motif chemokine receptor 8 Neighboring gene STARR-positive B cell enhancer ABC_E3867 Neighboring gene STARR-positive B cell enhancer ABC_E2312 Neighboring gene solute carrier family 25, member 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding  
    enables C-C chemokine receptor activity  
    enables C-X3-C chemokine binding PubMed 
    enables C-X3-C chemokine binding  
    enables C-X3-C chemokine receptor activity PubMed 
    enables C-X3-C chemokine receptor activity  
    enables CX3C chemokine receptor binding  
    enables CX3C chemokine receptor binding  
    enables G protein-coupled receptor activity PubMed 
    enables chemokine receptor activity  
    enables cytokine receptor activity PubMed 
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in adaptive immune response PubMed 
    involved_in antifungal innate immune response PubMed 
    involved_in antifungal innate immune response  
    involved_in autocrine signaling  
    involved_in autocrine signaling  
    involved_in brain development PubMed 
    involved_in calcium-mediated signaling  
    involved_in cell adhesion PubMed 
    involved_in cell adhesion  
    involved_in cell chemotaxis  
    involved_in cell chemotaxis  
    involved_in cell-cell adhesion  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in central nervous system maturation PubMed 
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemotaxis  
    involved_in host-mediated regulation of intestinal microbiota composition PubMed 
    involved_in immune response  
    involved_in immune response PubMed 
    involved_in innate immune response PubMed 
    involved_in leukocyte chemotaxis PubMed 
    involved_in leukocyte tethering or rolling PubMed 
    involved_in memory  
    involved_in memory  
    involved_in microglial cell activation  
    involved_in microglial cell activation involved in immune response PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in multiple spine synapse organization, single dendrite PubMed 
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of chronic inflammatory response to non-antigenic stimulus  
    involved_in negative regulation of hippocampal neuron apoptotic process  
    involved_in negative regulation of hippocampal neuron apoptotic process  
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of interleukin-1 beta production  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of long-term synaptic potentiation  
    involved_in negative regulation of microglial cell mediated cytotoxicity PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of I-kappaB phosphorylation  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of microglial cell migration  
    involved_in positive regulation of microglial cell migration  
    involved_in positive regulation of monocyte chemotaxis PubMed 
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of neurogenesis PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of nitric oxide biosynthetic process PubMed 
    involved_in regulation of tumor necrosis factor production PubMed 
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in social behavior PubMed 
    involved_in synapse maturation PubMed 
    involved_in synapse pruning PubMed 
    Items 1 - 25 of 67
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    located_in dendritic tree  
    located_in dendritic tree  
    is_active_in external side of plasma membrane  
    located_in neuronal cell body membrane  
    located_in neuronal cell body membrane  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    CX3C chemokine receptor 1
    Names
    C-X3-C CKR-1
    chemokine (C-X3-C motif) receptor 1
    chemokine (C-X3-C) receptor 1
    fractalkine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009987.4NP_034117.3  CX3C chemokine receptor 1

      See identical proteins and their annotated locations for NP_034117.3

      Status: VALIDATED

      Source sequence(s)
      AC117245, AK044557
      Consensus CDS
      CCDS40806.1
      UniProtKB/Swiss-Prot
      Q9Z0D9
      UniProtKB/TrEMBL
      Q543X3, Q8BR50, Q8CBJ0
      Related
      ENSMUSP00000063986.4, ENSMUST00000064165.5
      Conserved Domains (1) summary
      pfam00001
      Location:49294
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      119877749..119897362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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