Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk8ip1provided by MGI
Official Full Name: mitogen-activated protein kinase 8 interacting protein 1provided by MGI
Primary source: MGI:MGI:1309464
See related: Ensembl:ENSMUSG00000027223 AllianceGenome:MGI:1309464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IB1; Jip1; Skip; JIP-1; Prkm8ip; mjip-2a
Summary: Enables kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of DNA-templated transcription. Located in several cellular components, including dendrite; dentate gyrus mossy fiber; and neuronal cell body. Is expressed in several structures, including early conceptus; genitourinary system; musculature; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 70.7), cortex adult (RPKM 62.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.99 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (92214021..92231608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (92383671..92401346, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A point mutation in the Jip1 gene selectively blocks JIP1-mediated JNK activation. JIP1-mediated JNK activation contributes to the regulation of hippocampus-dependent, NMDAR-mediated synaptic plasticity and learning.
Title: JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory.
These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module.
Title: A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Phosphorylation of KLC1 at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP transport is impaired by aging. Authors conclude that phosphorylation of KLC1 at Thr466 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1b.
Title: Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.
It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Title: JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice.
Enhanced fast-velocity and efficient high-frequency APP anterograde transport observed in neurons are mediated by novel roles of JIP1b.
Title: Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
Title: Reassembly of JIP1 scaffold complex in JNK MAP kinase pathway using heterologous protein interactions.
There is a collaborative relationship between JIP1 and AKT that is required for axon growth and can be regulated by changes in neuronal activity.
Title: Regulation of axon growth by the JIP1-AKT axis.
identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.
Title: The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP transport in neurons.
Title: JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death
Title: Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE118974 (e-PCR)
- UniSTS:248915

BB392026 (e-PCR)
- UniSTS:207353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within JUN phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of CD8-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic growth cone	ISO Inferred from Sequence Orthology more info	PubMed
located_in dentate gyrus mossy fiber	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 1

Names: IB-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; islet-brain-1; protein kinase, mitogen-activated 8 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202445.1 → NP_001189374.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001189374.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK147033, BC072578

Consensus CDS

CCDS57180.1

UniProtKB/TrEMBL

Q6GQW8

Related

ENSMUSP00000106910.3, ENSMUST00000111279.9

Conserved Domains (2) summary

cd11943
Location:479 → 533

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

cd01212
Location:550 → 698

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
NM_001202446.1 → NP_001189375.1 C-Jun-amino-terminal kinase-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_001189375.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AK147033, BC072578

UniProtKB/TrEMBL

Q3UI81

Conserved Domains (2) summary

cd11943
Location:454 → 508

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

cd01212
Location:525 → 673

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
NM_011162.5 → NP_035292.2 C-Jun-amino-terminal kinase-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_035292.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL731709, BC072578

Consensus CDS

CCDS16446.1

UniProtKB/Swiss-Prot

O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8, Q9WVI9

UniProtKB/TrEMBL

Q6GQW8

Related

ENSMUSP00000050773.3, ENSMUST00000050312.3

Conserved Domains (2) summary

cd11943
Location:488 → 542

SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1

cd01212
Location:559 → 707

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain