Dgki diacylglycerol kinase, iota [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dgkiprovided by MGI
Official Full Name: diacylglycerol kinase, iotaprovided by MGI
Primary source: MGI:MGI:2443430
See related: Ensembl:ENSMUSG00000038665 AllianceGenome:MGI:2443430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6430604M11Rik; C130010K08Rik
Summary: Enables ATP-dependent diacylglycerol kinase activity; GTPase inhibitor activity; and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 B1

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (36814316..37281034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (36837381..37300955, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
Title: Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
These data suggest Dgki regulates sensory neuron and behavioral responses to histamine.
Title: Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables GTPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerolipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon terminus	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info	PubMed
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of guanyl-nucleotide exchange factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: diacylglycerol kinase iota

Names: DAG kinase iota

NP_001074675.1

EC 2.7.1.107

NP_001334033.1

EC 2.7.1.107

XP_006506321.1

EC 2.7.1.107

XP_006506322.1

EC 2.7.1.107

XP_011239687.1

EC 2.7.1.107

XP_017177113.1

EC 2.7.1.107

XP_017177114.1

EC 2.7.1.107

XP_017177115.1

EC 2.7.1.107

XP_017177116.1

EC 2.7.1.107

XP_017177117.1

EC 2.7.1.107

XP_017177118.1

EC 2.7.1.107

XP_017177119.1

EC 2.7.1.107

XP_017177121.1

EC 2.7.1.107

XP_017177122.1

EC 2.7.1.107

XP_030111313.1

EC 2.7.1.107

XP_030111314.1

EC 2.7.1.107

XP_036022113.1

EC 2.7.1.107

XP_036022114.1

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081206.2 → NP_001074675.1 diacylglycerol kinase iota isoform 1

Status: VALIDATED

Source sequence(s)

AC154019, AC159480, AK081360

Consensus CDS

CCDS39459.1

UniProtKB/Swiss-Prot

D3YWQ0, D3Z2W1

UniProtKB/TrEMBL

D3Z519

Related

ENSMUSP00000099071.4, ENSMUST00000101532.10

Conserved Domains (7) summary

smart00045
Location:521 → 678

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:373 → 494

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:869 → 1068

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:966 → 997

ANK; ANK repeat [structural motif]

pfam12796
Location:936 → 1031

Ank_2; Ankyrin repeats (3 copies)

cd20850
Location:163 → 235

C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins

cd20896
Location:244 → 318

C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
NM_001347104.2 → NP_001334033.1 diacylglycerol kinase iota isoform 2

Status: VALIDATED

Source sequence(s)

AC114574, AC154019, AC159480, AC184160

Consensus CDS

CCDS85032.1

UniProtKB/TrEMBL

D3Z519

Related

ENSMUSP00000087788.5, ENSMUST00000090314.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

36814316..37281034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506259.5 → XP_006506322.1 diacylglycerol kinase iota isoform X8

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:516 → 673

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:368 → 489

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:864 → 1063

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:961 → 992

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:931 → 1026

Ank_2; Ankyrin repeats (3 copies)
XM_011241385.4 → XP_011239687.1 diacylglycerol kinase iota isoform X16

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:520 → 677

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:372 → 493

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:832 → 1031

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:929 → 960

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:899 → 994

Ank_2; Ankyrin repeats (3 copies)
XM_006506258.5 → XP_006506321.1 diacylglycerol kinase iota isoform X7

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:520 → 677

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:372 → 493

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:868 → 1067

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:965 → 996

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:935 → 1030

Ank_2; Ankyrin repeats (3 copies)
XM_030255453.2 → XP_030111313.1 diacylglycerol kinase iota isoform X9

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:521 → 678

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:373 → 494

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:854 → 1053

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:951 → 982

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:921 → 1016

Ank_2; Ankyrin repeats (3 copies)
XM_017321628.3 → XP_017177117.1 diacylglycerol kinase iota isoform X5

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:561 → 718

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:413 → 534

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:888 → 1087

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:985 → 1016

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:955 → 1050

Ank_2; Ankyrin repeats (3 copies)
XM_017321625.3 → XP_017177114.1 diacylglycerol kinase iota isoform X2

Conserved Domains (6) summary

smart00045
Location:561 → 718

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:413 → 534

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:909 → 1108

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1006 → 1037

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:976 → 1071

Ank_2; Ankyrin repeats (3 copies)
XM_017321629.3 → XP_017177118.1 diacylglycerol kinase iota isoform X6

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:874 → 1073

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:971 → 1002

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:941 → 1036

Ank_2; Ankyrin repeats (3 copies)
XM_017321627.3 → XP_017177116.1 diacylglycerol kinase iota isoform X4

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:889 → 1088

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:986 → 1017

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:956 → 1051

Ank_2; Ankyrin repeats (3 copies)
XM_017321626.3 → XP_017177115.1 diacylglycerol kinase iota isoform X3

Conserved Domains (6) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:895 → 1094

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:992 → 1023

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:962 → 1057

Ank_2; Ankyrin repeats (3 copies)
XM_017321624.3 → XP_017177113.1 diacylglycerol kinase iota isoform X1

Conserved Domains (6) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:910 → 1109

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1007 → 1038

ANK; ANK repeat [structural motif]

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam12796
Location:977 → 1072

Ank_2; Ankyrin repeats (3 copies)
XM_036166220.1 → XP_036022113.1 diacylglycerol kinase iota isoform X13

UniProtKB/TrEMBL

D3Z519

Conserved Domains (6) summary

smart00045
Location:226 → 383

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:78 → 199

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:574 → 773

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:671 → 702

ANK; ANK repeat [structural motif]

pfam12796
Location:641 → 736

Ank_2; Ankyrin repeats (3 copies)

cl00040
Location:1 → 23

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_036166221.1 → XP_036022114.1 diacylglycerol kinase iota isoform X14

UniProtKB/TrEMBL

D3Z519

Conserved Domains (5) summary

smart00045
Location:196 → 353

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:48 → 169

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG0666
Location:544 → 743

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:641 → 672

ANK; ANK repeat [structural motif]

pfam12796
Location:611 → 706

Ank_2; Ankyrin repeats (3 copies)
XM_030255454.2 → XP_030111314.1 diacylglycerol kinase iota isoform X12

UniProtKB/TrEMBL

S4R2G0

Conserved Domains (3) summary

smart00045
Location:516 → 673

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:368 → 489

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_017321632.3 → XP_017177121.1 diacylglycerol kinase iota isoform X11

UniProtKB/TrEMBL

S4R2G0

Conserved Domains (3) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_017321630.3 → XP_017177119.1 diacylglycerol kinase iota isoform X10

UniProtKB/TrEMBL

S4R2G0

Related

ENSMUSP00000138628.2, ENSMUST00000138286.8

Conserved Domains (3) summary

smart00045
Location:562 → 719

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_017321633.3 → XP_017177122.1 diacylglycerol kinase iota isoform X15

UniProtKB/TrEMBL

S4R215

Related

ENSMUSP00000138457.2, ENSMUST00000150300.9

Conserved Domains (3) summary

smart00046
Location:414 → 535

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam00130
Location:246 → 303

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02440
Location:562 → 624

DAGK_acc; Diacylglycerol kinase accessory domain