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    Sv2b synaptic vesicle glycoprotein 2b [ Mus musculus (house mouse) ]

    Gene ID: 64176, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sv2bprovided by MGI
    Official Full Name
    synaptic vesicle glycoprotein 2bprovided by MGI
    Primary source
    MGI:MGI:1927338
    See related
    Ensembl:ENSMUSG00000053025 AllianceGenome:MGI:1927338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0735; A830038F04Rik
    Summary
    Predicted to enable transmembrane transporter activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2B (synaptic vesicle glycoprotein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 34.7), frontal lobe adult (RPKM 26.9) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sv2b in Genome Data Viewer
    Location:
    7 D1; 7 43.62 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (74764642..74959143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (75114894..75309262, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19211 Neighboring gene predicted gene, 53361 Neighboring gene STARR-seq mESC enhancer starr_19212 Neighboring gene RIKEN cDNA 4930533N22 gene Neighboring gene STARR-seq mESC enhancer starr_19213 Neighboring gene STARR-seq mESC enhancer starr_19214 Neighboring gene STARR-positive B cell enhancer ABC_E11357 Neighboring gene STARR-seq mESC enhancer starr_19215 Neighboring gene RIKEN cDNA 1500012K07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:82463213-82463514 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82507527-82507739 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82515952-82516252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:82516993-82517187 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82532718-82533019 Neighboring gene STARR-positive B cell enhancer mm9_chr7:82533022-82533322 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC38746

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in acrosomal vesicle  
    is_active_in glutamatergic synapse  
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    synaptic vesicle glycoprotein 2B
    Names
    synaptic vesicle glycoprotein 2 b
    synaptic vesicle protein 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109753.1NP_001103223.1  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_001103223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AK043830, AK147261, BC060224, BY269935
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000082254.6, ENSMUST00000085164.7
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    2. NM_001360571.1NP_001347500.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    3. NM_001360572.1NP_001347501.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    4. NM_001360573.1NP_001347502.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    5. NM_001360574.1NP_001347503.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC113471, AC116898, AC127355
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    6. NM_001360575.1NP_001347504.1  synaptic vesicle glycoprotein 2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      AC116898, AK029736, BC060224
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000146049.2, ENSMUST00000206344.2
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    7. NM_153579.4NP_705807.2  synaptic vesicle glycoprotein 2B

      See identical proteins and their annotated locations for NP_705807.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All seven variants encode the same protein.
      Source sequence(s)
      BC060224, BC079568
      Consensus CDS
      CCDS21368.1
      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Related
      ENSMUSP00000127245.2, ENSMUST00000165175.8
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      74764642..74959143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153323.1XP_036009216.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    2. XM_036153324.1XP_036009217.1  synaptic vesicle glycoprotein 2B isoform X1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
    3. XM_006541059.4XP_006541122.1  synaptic vesicle glycoprotein 2B isoform X1

      See identical proteins and their annotated locations for XP_006541122.1

      UniProtKB/Swiss-Prot
      Q80TT1, Q8BG39, Q9ES95
      Conserved Domains (1) summary
      TIGR01299
      Location:8683
      synapt_SV2; synaptic vesicle protein SV2
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