Rgs12 regulator of G-protein signaling 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs12provided by MGI
Official Full Name: regulator of G-protein signaling 12provided by MGI
Primary source: MGI:MGI:1918979
See related: Ensembl:ENSMUSG00000029101 AllianceGenome:MGI:1918979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130309H11; 1200016K18Rik; 4632412M04Rik
Summary: Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in termination of G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including apical dendrite; neuronal cell body; and nuclear lumen. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Predicted to colocalize with synapse. Is expressed in several structures, including heart; nervous system; placenta; trunk; and uterus. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 17.2), ovary adult (RPKM 9.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.96 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (35106273..35196988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (34948929..35039642)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
Title: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Title: RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.
Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo.
Title: Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo.
findings reveal that Rgs12 is an important regulator during osteogenesis and highlight Rgs12 as a potential therapeutic target for bone disorders.
Title: Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling.
Findings highlight a role for RGS12 as a novel, differential regulator of both G protein-dependent and -independent signaling downstream of KOR activation.
Title: Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior.
when mice lacking skeletal muscle expression of Rgs12 were cross-bred with mdx mice (a model of human Duchenne muscular dystrophy), no increase in muscle degeneration was observed over time
Title: A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation.
This study identified a novel role of Rgs12 in regulating Nrf2, thereby controlling cellular redox state and osteoclast differentiation.
Title: Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species.
RGS12 protein plays an important role in the pathogenesis of cardiac hypertrophy and could be a novel target for molecular therapy.
Title: Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy.
Rgs12 mutant mice had growth retardation with the phenotype of increased bone mass.
Title: Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype.
RGS12 splice variants exhibit differential spatiotemporal patterns of expression during postimplantation embryogenesis, suggesting nonoverlapping roles
Title: Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI481290 (e-PCR)
- UniSTS:159365

RH131193 (e-PCR)
- UniSTS:214476

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in termination of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
colocalizes_with synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: regulator of G-protein signaling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163512.2 → NP_001156984.1 regulator of G-protein signaling 12 isoform B

Status: VALIDATED

Source sequence(s)

AC126447

Consensus CDS

CCDS51472.1

UniProtKB/TrEMBL

E9Q1K7, Q9D677

Related

ENSMUSP00000109920.2, ENSMUST00000114281.8

Conserved Domains (7) summary

smart00455
Location:377 → 446

RBD; Raf-like Ras-binding domain

cd01817
Location:305 → 377

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:58 → 172

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:530 → 551

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

pfam16611
Location:448 → 518

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:593 → 703

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:178 → 275

RGS12_us1; Unstructured region of RGS12
NM_001403471.1 → NP_001390400.1 regulator of G-protein signaling 12 isoform A

Status: VALIDATED

Source sequence(s)

AC126447, AC133204

UniProtKB/Swiss-Prot

E9PXX2, Q8CGE9
NM_001403472.1 → NP_001390401.1 regulator of G-protein signaling 12 isoform C

Status: VALIDATED

Source sequence(s)

AC126447, AC133204
NM_001403473.1 → NP_001390402.1 regulator of G-protein signaling 12 isoform D

Status: VALIDATED

Source sequence(s)

AC126447

UniProtKB/TrEMBL

D3Z0G6, Q9D677

Related

ENSMUSP00000109923.2, ENSMUST00000114284.8
NM_001403474.1 → NP_001390403.1 regulator of G-protein signaling 12 isoform E

Status: VALIDATED

Source sequence(s)

AC126447

UniProtKB/TrEMBL

D3Z0G7
NM_001403475.1 → NP_001390404.1 regulator of G-protein signaling 12 isoform F

Status: VALIDATED

Source sequence(s)

AC126447

UniProtKB/TrEMBL

Q9D677
NM_001403476.1 → NP_001390405.1 regulator of G-protein signaling 12 isoform G

Status: VALIDATED

Source sequence(s)

AC126447
NM_001403477.1 → NP_001390406.1 regulator of G-protein signaling 12 isoform H

Status: VALIDATED

Source sequence(s)

AC126447
NM_001403478.1 → NP_001390407.1 regulator of G-protein signaling 12 isoform I

Status: VALIDATED

Source sequence(s)

AC126447

UniProtKB/TrEMBL

Q3TTW9

Related

ENSMUSP00000109919.2, ENSMUST00000114280.8
NM_173402.3 → NP_775578.2 regulator of G-protein signaling 12 isoform A

See identical proteins and their annotated locations for NP_775578.2

Status: VALIDATED

Source sequence(s)

AC126447, AC133204

Consensus CDS

CCDS19222.1

UniProtKB/Swiss-Prot

E9PXX2, Q8CGE9

Related

ENSMUSP00000030984.8, ENSMUST00000030984.14

Conserved Domains (9) summary

smart00455
Location:1035 → 1104

RBD; Raf-like Ras-binding domain

cd01817
Location:963 → 1035

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

pfam02188
Location:1188 → 1209

GoLoco; GoLoco motif

pfam16611
Location:1106 → 1176

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1251 → 1361

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 933

RGS12_us1; Unstructured region of RGS12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

35106273..35196988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504120.3 → XP_006504183.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006504183.1

UniProtKB/TrEMBL

E9Q652

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam02188
Location:1189 → 1209

GoLoco; GoLoco motif

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1361

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_036165494.1 → XP_036021387.1 regulator of G-protein signaling 12 isoform X2

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1378

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006504124.4 → XP_006504187.1 regulator of G-protein signaling 12 isoform X4

Conserved Domains (7) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1138

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006504121.4 → XP_006504184.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006504184.1

UniProtKB/TrEMBL

E9Q652

Related

ENSMUSP00000084970.5, ENSMUST00000087684.11

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam02188
Location:1189 → 1209

GoLoco; GoLoco motif

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1361

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006504122.4 → XP_006504185.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006504185.1

UniProtKB/TrEMBL

E9Q652

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 95

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam02188
Location:1189 → 1209

GoLoco; GoLoco motif

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1361

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006504125.5 → XP_006504188.1 regulator of G-protein signaling 12 isoform X5

UniProtKB/TrEMBL

D3Z0G7

Conserved Domains (7) summary

cd08742
Location:90 → 204

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd17136
Location:336 → 405

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam02188
Location:563 → 583

GoLoco; GoLoco motif

pfam16611
Location:480 → 554

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:612 → 735

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:210 → 323

RGS12_us1; Unstructured region of RGS12

cl28922
Location:406 → 478

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030254812.2 → XP_030110672.1 regulator of G-protein signaling 12 isoform X7

UniProtKB/TrEMBL

D3Z0G7

Conserved Domains (7) summary

smart00390
Location:387 → 408

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd17136
Location:161 → 230

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:305 → 379

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:437 → 560

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:35 → 148

RGS12_us1; Unstructured region of RGS12

cl02565
Location:1 → 29

RGS; Regulator of G protein signaling (RGS) domain superfamily

cl28922
Location:231 → 303

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006504126.5 → XP_006504189.1 regulator of G-protein signaling 12 isoform X6

UniProtKB/TrEMBL

D3Z0G5, D3Z0G7

Related

ENSMUSP00000109924.2, ENSMUST00000114285.8

Conserved Domains (7) summary

cd08742
Location:68 → 182

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd17136
Location:314 → 383

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam02188
Location:541 → 561

GoLoco; GoLoco motif

pfam16611
Location:458 → 532

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:590 → 713

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:188 → 301

RGS12_us1; Unstructured region of RGS12

cl28922
Location:384 → 456

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold