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    Cox10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 70383, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cox10provided by MGI
    Official Full Name
    heme A:farnesyltransferase cytochrome c oxidase assembly factor 10provided by MGI
    Primary source
    MGI:MGI:1917633
    See related
    Ensembl:ENSMUSG00000042148 AllianceGenome:MGI:1917633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410004F01Rik
    Summary
    Enables protoheme IX farnesyltransferase activity. Involved in heme O biosynthetic process. Acts upstream of or within several processes, including copper ion homeostasis; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in alimentary system; nervous system; respiratory system; and submandibular gland primordium. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 18.8), kidney adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cox10 in Genome Data Viewer
    Location:
    11 B3; 11 39.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (63853453..63970298, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (63962627..64079472, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29740 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 Neighboring gene STARR-positive B cell enhancer ABC_E1420 Neighboring gene STARR-seq mESC enhancer starr_29745 Neighboring gene STARR-seq mESC enhancer starr_29746 Neighboring gene RIKEN cDNA 9630013K17 gene Neighboring gene predicted gene, 30060 Neighboring gene predicted gene 12289 Neighboring gene predicted gene, 51866 Neighboring gene RIKEN cDNA 2810001G20 gene Neighboring gene STARR-seq mESC enhancer starr_29751 Neighboring gene STARR-seq mESC enhancer starr_29752 Neighboring gene STARR-seq mESC enhancer starr_29754 Neighboring gene predicted gene 12290

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within aerobic respiration PubMed 
    acts_upstream_of_or_within copper ion homeostasis PubMed 
    acts_upstream_of_or_within cytochrome complex assembly PubMed 
    involved_in heme A biosynthetic process  
    acts_upstream_of_or_within heme A biosynthetic process PubMed 
    involved_in heme A biosynthetic process PubMed 
    acts_upstream_of_or_within heme A biosynthetic process PubMed 
    involved_in heme A biosynthetic process  
    involved_in heme O biosynthetic process PubMed 
    acts_upstream_of_or_within leukocyte differentiation PubMed 
    involved_in lipid metabolic process  
    acts_upstream_of_or_within mitochondrial fission PubMed 
    acts_upstream_of_or_within mitochondrion organization PubMed 
    acts_upstream_of_or_within multicellular organism growth PubMed 
    acts_upstream_of_or_within protein farnesylation  
    involved_in respiratory chain complex IV assembly  
    involved_in respiratory chain complex IV assembly  
    Component Evidence Code Pubs
    part_of cytochrome complex  
    part_of cytochrome complex  
    located_in cytosol  
    located_in cytosol  
    is_active_in mitochondrial matrix PubMed 
    located_in mitochondrial membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  

    General protein information

    Preferred Names
    protoheme IX farnesyltransferase, mitochondrial
    Names
    COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
    cytochrome c oxidase assembly protein 10
    heme O synthase
    NP_848466.1
    XP_006534231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178379.3NP_848466.1  protoheme IX farnesyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_848466.1

      Status: VALIDATED

      Source sequence(s)
      AK149999, AL603889, BY078593
      Consensus CDS
      CCDS24839.1
      UniProtKB/Swiss-Prot
      Q8CFY5
      UniProtKB/TrEMBL
      Q3TAS4, Q3U3N1
      Related
      ENSMUSP00000040138.9, ENSMUST00000049091.9
      Conserved Domains (1) summary
      cd13957
      Location:159414
      PT_UbiA_Cox10; Protoheme IX farnesyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      63853453..63970298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534168.4XP_006534231.1  protoheme IX farnesyltransferase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd13957
      Location:1198
      PT_UbiA_Cox10; Protoheme IX farnesyltransferase
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